Glioma stem cells and their roles within the hypoxic tumor microenvironment

被引：152

作者：

Boyd, Nathaniel H. ^{[1
]}

Tran, Anh Nhat ^{[2
]}

Bernstock, Joshua D. ^{[3
]}

Etminan, Tina ^{[4
]}

Jones, Amber B. ^{[1
]}

Gillespie, G. Yancey ^{[5
]}

Friedman, Gregory K. ^{[6
]}

Hjelmeland, Anita B. ^{[1
,5
]}

机构：

[1] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL 35294 USA

[2] Northwestern Univ, Dept Neurosurg, Chicago, IL 60611 USA

[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurosurg, Boston, MA 02115 USA

[4] Univ Alabama Birmingham, Dept Chem, Birmingham, AL 35294 USA

[5] Univ Alabama Birmingham, Dept Neurosurg, Birmingham, AL 35294 USA

[6] Univ Alabama Birmingham, Dept Pediat, Div Pediat Hematol & Oncol, Birmingham, AL 35294 USA

来源：

THERANOSTICS | 2021年 / 11卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

acidic stress; glioma; hypoxia; cancer stem cells; tumor microenvironment; CARBONIC-ANHYDRASE-IX; HUMAN GLIOBLASTOMA CELLS; INDUCIBLE FACTORS; DNA-REPAIR; INTRATUMORAL HETEROGENEITY; SIGNALING PATHWAYS; TISSUE PENETRATION; MALIGNANT GLIOMAS; UP-REGULATION; PRIMARY BRAIN;

D O I：

10.7150/thno.41692

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tumor microenvironments are the result of cellular alterations in cancer that support unrestricted growth and proliferation and result in further modifications in cell behavior, which are critical for tumor progression. Angiogenesis and therapeutic resistance are known to be modulated by hypoxia and other tumor microenvironments, such as acidic stress, both of which are core features of the glioblastoma microenvironment. Hypoxia has also been shown to promote a stem-like state in both non-neoplastic and tumor cells. In glial tumors, glioma stem cells (GSCs) are central in tumor growth, angiogenesis, and therapeutic resistance, and further investigation of the interplay between tumor microenvironments and GSCs is critical to the search for better treatment options for glioblastoma. Accordingly, we summarize the impact of hypoxia and acidic stress on GSC signaling and biologic phenotypes, and potential methods to inhibit these pathways.

引用

页码：665 / 683

页数：19

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