Complete sequence of a duck astrovirus associated with fatal hepatitis in ducklings

被引：86

作者：

Fu, Yu ^{[1
]}

Pan, Meng ^{[1
]}

Wang, Xiaoyan ^{[1
]}

Xu, Yongliang ^{[1
]}

Xie, Xiaoyu ^{[1
]}

Knowles, Nick J. ^{[2
]}

Yang, Hanchun ^{[1
]}

Zhang, Dabing ^{[1
]}

机构：

[1] China Agr Univ, Coll Vet Med, Minist Agr, Key Lab Zoonosis, Beijing 100193, Peoples R China

[2] AFRC, Inst Anim Hlth, Pirbright Lab, Woking GU24 0NF, Surrey, England

来源：

JOURNAL OF GENERAL VIROLOGY | 2009年 / 90卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

MOLECULAR CHARACTERIZATION; VIRUS; RNA; IDENTIFICATION; EXPRESSION; SEROTYPES; REGION; TURKEY; MOTIF;

D O I：

10.1099/vir.0.008599-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Duck astroviruses (DAstVs) are known to cause duck viral hepatitis; however, little is known regarding their molecular biology. Here, we report the complete sequence of a DAstV associated with a recent outbreak of fatal hepatitis in ducklings in China. Sequence analyses indicated that the genome of DAstV possessed a typical astrovirus organization and also exhibited two unique features. The polyadenylated genome comprised 7722 nt, which is the largest among astroviruses sequenced to date. The ORF2 of DAstV was not in the same reading frame as either ORF1a or ORF1b, which was distinct from all other astroviruses. Sequence comparisons and phylogenetic analyses revealed that DAstV was more closely related to turkey astrovirus (TAstV) type 2, TAstV-3 and TAstV/MN/01 (a possible new TAstV serotype) than to TAstV-1 or other astroviruses. These findings suggest that astroviruses may transmit across ducks and turkeys.

引用

页码：1104 / 1108

页数：5

共 37 条

[1]

ASPLIN FD, 1965, VET REC, V77, P1529

[2] Novel astroviruses in insectivorous bats [J].

Chu, D. K. W. ;

Poon, L. L. M. ;

Guan, Y. ;

Peiris, J. S. M. .

JOURNAL OF VIROLOGY, 2008, 82 (18) :9107-9114

[3] Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea [J].

Finkbeiner, Stacy R. ;

Kirkwood, Carl D. ;

Wang, David .

VIROLOGY JOURNAL, 2008, 5 (1)

[4] Molecular detection and typing of duck hepatitis A virus directly from clinical specimens [J].

Fu, Yu ;

Pan, Meng ;

Wang, Xiaoyan ;

Xu, Yongliang ;

Yang, Hanchun ;

Zhang, Dabing .

VETERINARY MICROBIOLOGY, 2008, 131 (3-4) :247-257

[5] AN OUTBREAK OF DUCK HEPATITIS TYPE-II IN COMMERCIAL DUCKS [J].

GOUGH, RE ;

BORLAND, ED ;

KEYMER, IF ;

STUART, JC .

AVIAN PATHOLOGY, 1985, 14 (02) :227-&

[6] ASTROVIRUS-LIKE PARTICLES ASSOCIATED WITH HEPATITIS IN DUCKLINGS [J].

GOUGH, RE ;

COLLINS, MS ;

BORLAND, E ;

KEYMER, LF .

VETERINARY RECORD, 1984, 114 (11) :279-279

[7] INVITRO ISOLATION, PROPAGATION, AND CHARACTERIZATION OF DUCK HEPATITIS-VIRUS TYPE-III [J].

HAIDER, SA ;

CALNEK, BW .

AVIAN DISEASES, 1979, 23 (03) :715-729

[8] Avian nephritis virus (ANV) as a new member of the family Astroviridae and construction of infectious ANV cDNA [J].

Imada, T ;

Yamaguchi, S ;

Mase, M ;

Tsukamoto, K ;

Kubo, M ;

Morooka, A .

JOURNAL OF VIROLOGY, 2000, 74 (18) :8487-8493

[9] RNA SEQUENCE OF ASTROVIRUS - DISTINCTIVE GENOMIC ORGANIZATION AND A PUTATIVE RETROVIRUS-LIKE RIBOSOMAL FRAMESHIFTING SIGNAL THAT DIRECTS THE VIRAL REPLICASE SYNTHESIS [J].

JIANG, BM ;

MONROE, SS ;

KOONIN, EV ;

STINE, SE ;

GLASS, RI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (22) :10539-10543

[10] A common RNA motif in the 3′ end of the genomes of astroviruses, avian infectious bronchitis virus and an equine rhinovirus [J].

Jonassen, CM ;

Jonassen, TO ;

Grinde, B .

JOURNAL OF GENERAL VIROLOGY, 1998, 79 :715-718

← 1 2 3 4 →