Update on the Treatment of the Pruritus of Cholestasis

被引：17
作者：
Bergasa, Nora V. [1 ,2 ]
机构：
[1] Woodhull Med & Mental Hlth Ctr, Dept Med, Brooklyn, NY 11026 USA
[2] SUNY Downstate, Brooklyn, NY USA
来源：
CLINICS IN LIVER DISEASE | 2008年 / 12卷 / 01期
关键词：
PRIMARY BILIARY-CIRRHOSIS; CHRONIC LIVER-DISEASE; SERUM BILE-ACIDS; RECURRENT INTRAHEPATIC CHOLESTASIS; EXTRACORPOREAL ALBUMIN DIALYSIS; ORAL NALTREXONE TREATMENT; OPIOID RECEPTOR AGONIST; DOUBLE-BLIND; INTRACTABLE PRURITUS; CONTROLLED-TRIAL;
D O I：
10.1016/j.cld.2007.11.009
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The pruritus of cholestasis is a difficult clinical problem to manage. it can be severe and interfere with sleep. Clinical behavioral studies have confirmed that the pruritus is mediated at least in part by endogenous opioids. Other neurotransmitter systems may be involved in the mediation of pruritus. Work continues to identify the mechanisms that mediate the pruritus and to develop specific drugs to treat this often maddening symptom.
引用
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页码：219 / +
页数：17
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