Impacts of Dietary Protein from Fermented Cottonseed Meal on Lipid Metabolism and Metabolomic Profiling in the Serum of Broilers

被引:10
作者
Nie, Cunxi [1 ,2 ]
Wang, Yongqiang [1 ]
Liu, Yanfeng [1 ]
Liu, Jiancheng [1 ]
Ge, Wenxia [1 ]
Ma, Xi [1 ,2 ]
Zhang, Wenju [1 ]
机构
[1] Shihezi Univ, Coll Anim Sci & Technol, 221 Beisi Rd, Shihez 832003, Xinjiang, Peoples R China
[2] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Fermented cottonseed meal; lipid metabolism; broiler chicken; metabolomics; GC-TOF/MS; triglyceride; GROWTH-PERFORMANCE; BACILLUS-SUBTILIS; FAT DEPOSITION; AMINO-ACIDS; GOSSYPOL; SUPPLEMENTATION; MICROBIOTA; DISCOVERY; BUTYRATE; QUALITY;
D O I
10.2174/1389203721666200203152643
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dietary protein from fermented cottonseed meal (FCSM), widely used in poultry diets in China, had regulating effects on lipid metabolism. To understand the effects of FCSM on lipid metabolism in broilers, we analyzed the biochemical indexes, enzyme activity, hormone level and metabolites in serum responses to FCSM intake. One hundred and eighty 21-d-old Chinese yellow feathered broilers (536.07 +/- 4.43 g) were randomly divided into 3 groups with 6 replicates and 3 diets with 6 % supplementation of unfermented CSM (control group), FCSM by C. Tropicalis (Ct CSM) or C. tropicalis plus S. Cerevisae (Ct-Sc CSM). Result showed that: (1) FCSM intake decreased significantly the content of triglyceride (TAG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (P<0.05) in serum; (2) FCSM intake could significantly increase enzyme activity of acetyl CoA carboxylase (ACC), lipoprotein lipase (LPL), fatty acid synthase (FAS) and hormone sensitive lipase (HSL) (P<0.05); (3) Ct-Sc CSM intake increased significantly the levels of adiponectin (ADP) (P<0.05); (4) FCSM intake caused significant metabolic changes involving glycolysis, TCA cycle, synthesis of fatty acid and glycogen, and metabolism of glycerolipid, vitamins B group and amino acids. Our results strongly suggested that FCSM intake could significantly affect lipid metabolism via multiple pathways. These findings provided new essential information about the effect of FCSM on broilers and demonstrated the great potential of nutrimetabolomics, through which the research complex nutrients are included in animal diet.
引用
收藏
页码:812 / 820
页数:9
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