The roles of cutaneous lipids in host defense

被引：64

作者：

Fischer, Carol L. ^{[1
]}

Blanchette, Derek R. ^{[1
]}

Brogden, Kim A. ^{[1
]}

Dawson, Deborah V. ^{[1
]}

Drake, David R. ^{[1
]}

Hill, Jennifer R. ^{[2
]}

Wertz, Philip W. ^{[1
]}

机构：

[1] Univ Iowa, Dows Inst, Iowa City, IA 52242 USA

[2] Georgia Regents Univ, Dept Pediat Dent, Augusta, GA USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2014年 / 1841卷 / 03期

关键词：

Sphingosine; Dihydrosphingosine; Phytosphingosine; Lauric acid; Sapienic acid; Antimicrobial; ANTIMICROBIAL ACTIVITY; STRATUM-CORNEUM; FATTY-ACIDS; ATOPIC-DERMATITIS; SPHINGOID BASES; SKIN; VULNERABILITY; COLONIZATION; PERMEABILITY; BARRIERS;

D O I：

10.1016/j.bbalip.2013.08.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lauric acid (C12:0) and sapienic acid (C16:1 Delta 6) derived from human sebaceous triglycerides are potent antimicrobials found at the human skin surface. Long-chain bases (sphingosine, dihydrosphingosine and 6-hydroxysphingosine) are also potent and broad-acting antimicrobials normally present at the skin surface. These antimicrobials are generated through the action of ceramidases on ceramides from the stratum corneum. These natural antimicrobials are thought to be part of the innate immune system of the skin. Exogenously providing these lipids to the skin may provide a new therapeutic option, or could potentially provide prophylaxis in people at risk of infection. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：319 / 322

页数：4

共 40 条

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