Hepatoprotective effect of Diospyros lotus leaf extract against acetaminophen-induced acute liver injury in mice

被引：14

作者：

Cho, Byoung Ok ^{[1
,2
]}

Yin, Hong Hua ^{[1
]}

Fang, Chong Zhou ^{[2
]}

Kim, Sang Jun ^{[3
]}

Jeong, Seung Il ^{[3
]}

Jang, Seon Il ^{[1
,2
]}

机构：

[1] Ato Q&A Corp, Jeonju 55069, Jeonbuk, South Korea

[2] Jeonju Univ, Dept Hlth & Sci, Jeonju 55069, Jeonbuk, South Korea

[3] Jeonju Biomat Inst, Jeonju 54810, Jeonbuk, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2015年 / 24卷 / 06期

关键词：

Diospyros lotus; acetaminophen; liver injury; antioxidants; anti-inflammation; MEDIATED DNA-DAMAGE; CARBON-TETRACHLORIDE; INDUCED HEPATOTOXICITY; CAFFEIC ACID; ANTIOXIDANT; PROTECTS; RATS; TOXICITY; ANIMALS;

D O I：

10.1007/s10068-015-0294-6

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The aim of this study was to investigate the protective effect of Diospyros lotus leaf extract (DLE) against acetaminophen (APAP)-induced acute liver injury in mice. Administration of DLE significantly attenuated the levels of serum aspartate aminotransferase, alanine aminotransferase, and liver lipid peroxidation in APAP-treated mice. Histopathological examination showed that DLE treatment decreased the incidence of liver lesions in APAP-treated mice. DLE treatment markedly increased superoxide dismutase, catalase, glutathione peroxidase activity, and glutathione levels in APAP-treated mice. Furthermore, DLE treatment significantly suppressed the production of proinflammatory factors such as the nitric oxide, IL-6, TNF-alpha, and iNOS in APAP-treated mice. These results suggest that DLE protects the liver from APAP-induced hepatic injury via antioxidant and antiinflammatory effects.

引用

页码：2205 / 2212

页数：8

共 35 条

[1] Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride [J].

Adesanoye, Omolola A. ;

Farombi, Ebenezer O. .

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2010, 62 (02) :197-206

[2] Hesperidin alleviates acetaminophen induced toxicity in wistar rats by abrogation of oxidative stress, apoptosis and inflammation [J].

Ahmad, Shiekh Tanveer ;

Arjumand, Wani ;

Nafees, Sana ;

Seth, Amlesh ;

Ali, Nemat ;

Rashid, Summya ;

Sultana, Sarwat .

TOXICOLOGY LETTERS, 2012, 208 (02) :149-161

[3] Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmention in acetaminophen-induced hepatotoxicity [J].

Ajiboye, T. O. .

JOURNAL OF ETHNOPHARMACOLOGY, 2015, 164 :273-282

[4] Acetaminophen perturbed redox homeostasis in Wistar rat liver: protective role of aqueous Pterocarpus osun leaf extract [J].

Ajiboye, Taofeek O. ;

Salau, Amadu K. ;

Yakubu, Musa T. ;

Oladiji, Adenike T. ;

Akanji, Musbau A. ;

Okogun, Joseph I. .

DRUG AND CHEMICAL TOXICOLOGY, 2010, 33 (01) :77-87

[5] The interaction of hepatic lipid and glucose metabolism in liver diseases [J].

Bechmann, Lars P. ;

Hannivoort, Rebekka A. ;

Gerken, Guido ;

Hotamisligil, Goekhan S. ;

Trauner, Michael ;

Canbay, Ali .

JOURNAL OF HEPATOLOGY, 2012, 56 (04) :952-964

[6] Antiepileptogenic, antioxidant and genotoxic evaluation of rosmarinic acid and its metabolite caffeic acid in mice [J].

Coelho, Vanessa Rodrigues ;

Vieira, Caroline Goncalves ;

de Souza, Luana Pereira ;

Moyses, Felipe ;

Basso, Carla ;

Mausolff Papke, Debora Kuck ;

Pires, Thienne Rocha ;

Siqueira, Ionara Rodrigues ;

Picada, Jaqueline Nascimento ;

Pereira, Patricia .

LIFE SCIENCES, 2015, 122 :65-71

[7] Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice [J].

Domitrovic, Robert ;

Rashed, Khaled ;

Cvijanovic, Olga ;

Vladimir-Knezevic, Sanda ;

Skoda, Marko ;

Visnic, Alenka .

CHEMICO-BIOLOGICAL INTERACTIONS, 2015, 230 :21-29

[8] Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria [J].

Fang, Shih-Hua ;

Rao, Yerra Koteswara ;

Tzeng, Yew-Min .

JOURNAL OF ETHNOPHARMACOLOGY, 2008, 116 (02) :333-340

[9] Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity [J].

Fouad, Amr A. ;

Jresat, Iyad .

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2012, 33 (02) :158-167

[10] Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice [J].

Girish, C. ;

Pradhan, S. C. .

JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS, 2012, 3 (02) :149-155

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