Quality of life evaluation in oncological clinical trials - the EORTC model

被引：65

作者：

de Haes, J

Curran, D

Young, T

Bottomley, A

Flechtner, H

Aaronson, N

Blazeby, J

Bjordal, K

Brandberg, Y

Greimel, E

Maher, J

Sprangers, M

Cull, A

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Med Psychol, NL-1100 DD Amsterdam, Netherlands

[2] EORTC Qual Life Unit, Brussels, Belgium

[3] Mt Vernon Hosp, Northwood, Middx, England

[4] Klin Psychiat & Psychotherapie, Cologne, Germany

[5] Netherlands Canc Inst, Amsterdam, Netherlands

[6] Bristol Royal Infirm, Bristol, Avon, England

[7] Natl Hosp Norway, Oslo, Norway

[8] Karolinska Hosp, S-10401 Stockholm, Sweden

[9] Graz Univ, Graz, Austria

[10] Acad Med Hosp, Amsterdam, Netherlands

[11] Western Gen Hosp, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 07期

关键词：

quality of life assessment; liaison function; protocol development;

D O I：

10.1016/S0959-8049(00)00007-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The European Organization for Research and Treatment of Cancer (EORTC) has taken a leading role in the development of the methodology of quality of life (QL) measurement. In the EORTC Quality of Life Study Group (QLSG) valid instruments to assess QL in a general manner and disease-specific modules have been developed to be used in oncological clinical trials. Statistical and methodological aspects of QL research are discussed. The application of QL assessments in clinical trials represents a subsequent challenge. To improve the practice of QL assessment in clinical trials an 'EORTC model' has been developed. This model requires the collaboration of liaison persons, the EORTC Cooperative Tumour Groups and the EORTC Data Centre Quality of Life Unit (QL Unit). Cooperation between these parties, protocol development and advantages and concerns of the model are mentioned in this paper. Finally, suggestions for improvement are proposed. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：821 / 825

页数：5

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