Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?

被引：110

作者：

Ahner, A ^{[1
]}

Brodsky, JL ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 09期

关键词：

D O I：

10.1016/j.tcb.2004.07.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The failure of secreted proteins to fold results in their retrotranslocation from the endoplasmic reticulum (ER) and degradation by the proteasome in a process called 'ER-associated degradation' (ERAD). Two recent studies indicate that ERAD substrates are targeted to different pathways depending on the topology of the substrate and the subcellular location of the misfolded domain.

引用

页码：474 / 478

页数：5

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