Atorvastatin does not alter the anticoagulant activity of warfarin

被引：33
作者：
Stern, R
Abel, R
Gibson, GL
Besserer, J
机构：
[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES,DEPT BIOMETR,ANN ARBOR,MI
[2] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES,DEPT CLIN COMMUN,ANN ARBOR,MI
[3] NEUROL ASSOCIATES PA,LITTLE ROCK,AR
来源：
JOURNAL OF CLINICAL PHARMACOLOGY | 1997年 / 37卷 / 11期
关键词：
D O I：
10.1002/j.1552-4604.1997.tb04288.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Twelve patients chronically maintained on warfarin were administered 80 mg atorvastatin for 2 weeks. Mean prothrombin times decreased slightly, but only for the first few days of the two-week treatment period. Thus atorvastatin had no consistent effect on the anticoagulant activity of warfarin and adjustments in warfarin dosing should not be necessary.
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页码：1062 / 1064
页数：3
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