Deciphering the Role of miRNAs in Endometriosis Pathophysiology Using Experimental Endometriosis Mouse Models

被引：3

作者：

Vashisht, Ayushi ^{[1
]}

Alali, Zahraa ^{[1
]}

Nothnick, Warren B. ^{[1
,2
,3
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66103 USA

[2] Univ Kansas, Med Ctr, Dept Obstet & Gynecol, Kansas City, KS 66103 USA

[3] Univ Kansas, Med Ctr, Inst Reprod & Perinatal Res, Ctr Reprod Sci, Kansas City, KS 66103 USA

来源：

ANIMAL MODELS FOR ENDOMETRIOSIS: EVOLUTION, UTILITY AND CLINICAL RELEVANCE | 2020年 / 232卷

关键词：

Endometriosis; miRNA; Mouse model; Steroid; Uterus; MESENCHYMAL STEM-CELLS; INHIBITS PROLIFERATION; MICRORNA EXPRESSION; STROMAL CELLS; REGULATES VEGFA; DOWN-REGULATION; IN-VITRO; WOMEN; PATHOGENESIS; APOPTOSIS;

D O I：

10.1007/978-3-030-51856-1_5

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Endometriosis is an enigmatic disease for which we still have a poor understanding on how and why the disease develops. In recent years, miRNAs, small noncoding RNAs which regulate gene expression posttranscriptionally, have been evaluated for their role in endometriosis pathophysiology. This review will provide a brief summary on the role of miRNAs in endometrial physiology and pathophysiology as related to endometriosis. We will then discuss mouse models used in endometriosis research and the incorporation of some of these models in studies which examined the role of miRNAs in endometriosis pathophysiology. We conclude with providing future prospective on the role of mouse models in dissecting the role of miRNAs in endometriosis pathophysiology.

引用

页码：79 / 97

页数：19

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