The regulatory role of dendritic cells in the immune response

被引：18

作者：

Granucci, F ^{[1
]}

Zanoni, I ^{[1
]}

Feau, S ^{[1
]}

Capuano, G ^{[1
]}

Ricciardi-Castagnoli, P ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Biosci & Biotechnol, IT-20126 Milan, Italy

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2004年 / 134卷 / 03期

关键词：

dendritic cells; interleukin-2; immune response; innate; adaptive; cytoskeleton;

D O I：

10.1159/000078764

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are key regulators of immune reactions. They control early innate responses, regulate long-lasting adaptive immunity and contribute to the maintenance of self-tolerance. DCs continuously monitor the environment through a multifaceted innate antigen receptor repertoire and, in response to perturbations, start a complex genetic reprogramming that leads to a complete activation of innate and, then, adaptive immune responses. This review discusses how DCs become efficient activators of NK and, subsequently, T cells following a microbial encounter. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：179 / 185

页数：7

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