OPIOIDS AND COGNITION BY PATIENTS WITH CHRONIC PAIN: A SYSTEMATIC REVIEW

被引:8
作者
Kurita, Geana Paula [1 ]
De Mattos Pimenta, Cibele Andrucioli [1 ]
Cuce Nobre, Moacyr Roberto [1 ]
机构
[1] Univ Sao Paulo, Escola Enfermagem, Curso Posgrad Enfermagem Saude Adulto, Sao Paulo, Brazil
来源
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | 2008年 / 54卷 / 06期
关键词
Pain; Cancer; Cognition; Opioids; Systematic review;
D O I
10.1590/S0104-42302008000600018
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE. The increasing use of opioids by patients suffering from chronic pain caused by different etiologies, and the possible effects of those substances on everyday activities, require careful evaluation of their effects. For this purpose, a systematic review was developed to assess the influence of opioids on the cognitive function in patients with chronic pain. METHODS. Eleven databases were analyzed using the following descriptors: opioids, opiates, narcotics, cognitive impairment, cognitive dysfunction, cognitive disorders and pain. The inclusion criteria were: clinical trials or case reports which included patients with chronic pain in treatment with opioids, cognitive assessment by specific tests and publication in English, Spanish or Portuguese. RESULTS. Sixteen surveys published between 1980 and 2004 met the criteria: six controlled trials, two randomized trials, and 10 studies of a lower scientific evidence level. All better quality controlled trials did not show cognitive impairment of patients under opioid therapy. CONCLUSION. These results must be confirmed by additional randomized trials including a greater number of patients with chronic pain. [Rev Assoc Med Bras 2008; 54(6): 529-36]
引用
收藏
页码:529 / 536
页数:8
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