The Effects of Different Anesthetic Agents on Short Electroretinography Protocol in Dogs

The purpose of this article was to investigate the effects of sedatives and general anesthetics, such as tiletamine-zolazepam, medetomidine, and isoflurane oil the short ERG protocol. Six healthy mongrel dogs were assessed by a convenient short ERG protocol with the owners' consent. The amplitudes of a-wave and b-wave, as well as the implicit time of ERG under different anesthesia statuses, were recorded and analyzed. The amplitudes of ERG waves were not significantly different between tiletamine-zolazepam and medetomidine groups, except in b-wave after 5 min dark adaptation (140 +/- 42 mu V in tiletamine-zolazepam and 101 +/- 32 mu V in medetomidine, p<0.01). The amplitude of ERG recorded in isoflurane (5 +/- 3 mu Vof a-wave and 12 +/- 6 mu V of b-wave under light adaptation; 41 +/- 19 mu V of b-wave after 1 min dark adaptation; 28 +/- 15 of a-wave and 58 +/- 32 /N of b-wave after 5 min dark adaptation) were significantly different from tiletarnine-zolazepain (8 +/- 2 mu V of a-wave and 24 +/- 9 mu V of b-wave under light adaptation; 117 +/- 44 mu V of b-wave after I min dark adaptation; 59 18 IN of a-wave and 140 42 IN of b-wave after 5 min dark adaptation), except in a-wave after I min dark adaptation (39 +/- 13 mu V in tiletamine-zolazepam and 34 +/- 17 mu V in isoflurane). Comment-General anesthesia had significantly lower amplitudes in the dark-adapted group compared with the sedation group. Therefore, tiletamine-zolazepam is a desirable choice for the short ERG protocol in dogs.