Clinical Evidence on Hemodiafiltration: A Systematic Review and a Meta- analysis

被引：101

作者：

Mostovaya, Ira M. ^{[1
]}

Blankestijn, Peter J. ^{[1
]}

Bots, Michiel L. ^{[2
]}

Covic, Adrian ^{[3
]}

Davenport, Andrew ^{[4
]}

Grooteman, Muriel P. C. ^{[5
,6
]}

Hegbrant, Joergen ^{[7
]}

Locatelli, Francesco ^{[8
]}

Vanholder, Raymond ^{[9
]}

Nube, Menso J. ^{[5
,6
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Nephrol, Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[3] Gr T Popa Univ Med & Pharm, CI Parhon Univ Hosp, Dialysis & Renal Transplant Ctr, Nephrol Clin, Iasi, Romania

[4] UCL, Sch Med, Royal Free Hosp, UCL Ctr Nephrol, London W1N 8AA, England

[5] Vrije Univ Amsterdam Med Ctr, Dept Nephrol, Amsterdam, Netherlands

[6] Vrije Univ Amsterdam Med Ctr, VU Med Ctr ICaR VU, Inst Cardiovasc Res, Amsterdam, Netherlands

[7] Diaverum Renal Serv Grp, Lund, Sweden

[8] Alessandro Manzoni Hosp, Dept Nephrol Dialysis & Renal Transplantat, Lecce, Italy

[9] Univ Hosp, Dept Internal Med, Nephrol Sect, Ghent, Belgium

来源：

SEMINARS IN DIALYSIS | 2014年 / 27卷 / 02期

关键词：

PATIENTS RECEIVING HEMODIAFILTRATION; ALL-CAUSE MORTALITY; ONLINE HEMODIAFILTRATION; REMAINING QUESTIONS; HEMODIALYSIS; DIALYSIS; PATIENT; RISK; ESRD;

D O I：

10.1111/sdi.12200

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In this review, a systematic literature search and meta-analysis were performed to assess the effects of hemodiafiltration (HDF) on clinical outcome, as compared with hemodialysis (HD). Furthermore, the relation between the convection volume in HDF and clinical outcome was studied. The literature search identified six randomized controlled trials (RCTs). In a meta-analysis of these RCTs, HDF treatment was related to a decreased risk of mortality (RR: 0.84; 95% CI 0.73-0.96) and cardiovascular death (RR: 0.73; 95% CI 0.57-0.92). Post hoc analyses of the three largest RCTs suggested an inverse relation between the magnitude of convection volume and mortality risk. The evidence presented in this analysis supports a wider acceptance of HDF.

引用

页码：119 / 127

页数：9

共 25 条

[1]

[Anonymous], METAANALYSIS CLIN EP

[2] Has the Time Now Come to More Widely Accept Hemodiafiltration in the United States? [J].

Blankestijn, Peter J. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 24 (03) :332-334

[3] Haemodiafiltration: becoming the new standard? In Focus [J].

Blankestijn, Peter J. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2013, 28 (01) :1-2

[4] Hemodiafiltration: clinical evidence and remaining questions [J].

Blankestijn, Peter J. ;

Ledebo, Ingrid ;

Canaud, Bernard .

KIDNEY INTERNATIONAL, 2010, 77 (07) :581-587

[5]

Bosch Juan P, 2006, Hemodial Int, V10, P73, DOI 10.1111/j.1542-4758.2006.01178.x

[6] Mortality risk for patients receiving hemodiafiltration versus hemodialysis: European results from the DOPPS [J].

Canaud, B. ;

Bragg-Gresham, J. L. ;

Marshall, M. R. ;

Desmeules, S. ;

Gillespie, B. W. ;

Depner, T. ;

Klassen, P. ;

Port, F. K. .

KIDNEY INTERNATIONAL, 2006, 69 (11) :2087-2093

[7] Daily on line haemodiafiltration promotes catch-up growth in children on chronic dialysis [J].

Fischbach, Michel ;

Terzic, Joelle ;

Menouer, Soraya ;

Dheu, Celine ;

Seuge, Laure ;

Zalosczic, Ariane .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2010, 25 (03) :867-873

[8]

Fleiss J L, 1993, Stat Methods Med Res, V2, P121, DOI 10.1177/096228029300200202

[9] Effect of Online Hemodiafiltration on All-Cause Mortality and Cardiovascular Outcomes [J].

Grooteman, Muriel P. C. ;

van den Dorpel, Marinus A. ;

Bots, Michiel L. ;

Penne, E. Lars ;

van der Weerd, Neelke C. ;

Mazairac, Albert H. A. ;

den Hoedt, Claire H. ;

van der Tweel, Ingeborg ;

Levesque, Renee ;

Nube, Menso J. ;

ter Wee, Piet M. ;

Blankestijn, Peter J. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (06) :1087-1096

[10]

Han Sang Youb, 2000, Korean Journal of Internal Medicine, V15, P81

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