Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors

被引：32

作者：

Chen, Jianyang ^{[1
]}

Peng, Haixia ^{[1
]}

He, Jinxue ^{[2
]}

Huan, Xiajuan ^{[2
]}

Miao, Zehong ^{[2
]}

Yang, Chunhao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Dept Med Chem, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Isoquinolinone-based tricycles; PARP-1; inhibitors; Antitumor; CANCER; REPAIR; CELLS; THERAPY; DESIGN;

D O I：

10.1016/j.bmcl.2014.04.061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The isoquinolinone-based tricyclic compounds were designed and synthesized. Preliminary biological study of these compounds provided potent compounds 17a, 33b, 33c, 33d, and 33g with low nanomolar IC(50)s against PARP-1 enzyme. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：2669 / 2673

页数：5

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