FGFR4 and TGF-β1 Expression in Hepatocellular Carcinoma: Correlation with Clinicopathological Features and Prognosis

被引：27

作者：

Chen, Zhixin ^{[1
]}

Xie, Bao ^{[1
,2
]}

Zhu, Qinhua ^{[1
]}

Xia, Qinghai ^{[1
]}

Jiang, Songmin ^{[3
]}

Cao, Ruoyu ^{[4
]}

Shi, Lihua ^{[1
]}

Qi, Dansi ^{[2
]}

Li, Xiaokun ^{[1
]}

Cai, Lin ^{[1
]}

机构：

[1] Wenzhou Med Univ, Sch Pharm, Dept Biopharmaceut, Wenzhou, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 2, Dept Pathol, Wenzhou, Zhejiang, Peoples R China

[3] Wenzhou Ruian Peoples Hosp, Dept Pharm, Wenzhou, Zhejiang, Peoples R China

[4] Cangzhou Cent Hosp, Dept Pediat, Cangzhou, Hebei, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2013年 / 10卷 / 13期

基金：

中国国家自然科学基金;

关键词：

TGF-beta; 1; FGFR4; hepatocellular carcinoma; immunohistochemistry; prognosis; FIBROBLAST-GROWTH-FACTOR; FACTOR RECEPTOR 4; FACTOR-BETA; PROGRESSION; HEPATOCYTES; SPECIFICITY; MANAGEMENT; APOPTOSIS; FIBROSIS; ALPHA;

D O I：

10.7150/ijms.6868

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To investigate the expression and correlation of transforming growth factor-beta 1 (TGF-beta 1) and fibroblast growth factor receptor 4 (FGFR4) in human hepatocellular carcinoma (HCC) and the relationship with clinicopathological features and prognosis. Materials and methods: The expression of TGF-beta 1 and FGFR4 in 126 HCC samples was detected immunohistochemically. Combined with clinical postoperative follow-up data, the expression of TGF-beta 1 and FGFR4 in HCC and the relationship with the prognosis of patients were analyzed by statistically. Results: The positive expression rate of TGF-beta 1 was 84.1% (106/126) in tumors, and that in peritumoral liver tissues was 64.3% (81/126); the positive expression rate of FGFR4 in tumors was 74.6% (94/126) and that in peritumoral liver tissues was 57.1% (72/126). The expression of TGF-beta 1 and FGFR4 in the carcinoma tissues was significantly higher than that in peritumoral liver tissues (p < 0.05). Intratumoral TGF-beta 1 and FGFR4 expression was associated with TNM stage (p < 0.05). TGF-beta 1 and FGFR4 expression levels didn't significantly correlate with other clinicopathological parameters, including age, sex, tumor size, serum AFP level, tumor differentiation, lymph node metastasis, etc. (p > 0.05). TGF-beta 1 expression was positively correlated with FGFR4 expression (r = 0.595, p < 0.05). Patients with positive FGFR4 or TGF-beta 1 expression had shorter overall survival compared with negative expression (p < 0.05). Conclusions: The expression of TGF-beta 1 and FGFR4 could make synergy on the occurrence and progression of HCC, and may be used as prognosis indicators for HCC patients.

引用

页码：1868 / 1875

页数：8