T cell responses in dengue viral infections

被引:36
作者
Malavige, Gathsaurie Neelika [1 ,2 ,3 ]
Ogg, Graham S. [2 ,3 ,4 ]
机构
[1] Univ Sri Jayawardenapura, Fac Med Sci, Ctr Dengue Res, Dept Microbiol, Nugegoda, Sri Lanka
[2] Oxford NIHR Biomed Res Ctr, Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford OX3 9DS, England
[3] Univ Oxford, Oxford OX3 9DS, England
[4] Churchill Hosp, Dept Dermatol, Oxford OX3 7LJ, England
基金
英国医学研究理事会;
关键词
Dengue viral infection; T cells; Cytokines; Pathogenesis; Vascular leak; PRO-INFLAMMATORY CYTOKINES; ORIGINAL ANTIGENIC SIN; HEMORRHAGIC-FEVER; VIRUS; CD4(+); ACTIVATION; MONOCYTES; EPITOPES; ADULTS; PATHOGENESIS;
D O I
10.1016/j.jcv.2013.10.023
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Dengue viral infections are the commonest mosquito borne viral infection in the world, affecting more than 100 countries and 390 million individuals annually. Currently, there are no effective antiviral drugs or an effective vaccine to prevent infection. A main hurdle in developing a safe and effective vaccine has been our poor understanding of the complex nature of the protective immune response in acute dengue infection and the presence of four dengue virus (DV) serotypes that are highly homologous. The role of DV specific T cells in the pathogenesis of severe clinical disease in not clear. It has been speculated that highly cross reactive T cells for the previous infecting heterologous DV serotype, which produce pro-inflammatory cytokines, contribute to disease pathogenesis. These cross reactive T cells are believed to be suboptimal in clearing the infection with the current DV-serotype. However, other studies have shown that cross-reactive DV-specific T cells are absent or present in very low frequency during acute infection, appearing only during the convalescent period in the majority of patients. Furthermore, significant apoptosis of T cells occurs in severe acute clinical disease. Overall therefore, it is unclear what role T cells play in contributing to disease pathogenesis during acute dengue infection. Existing data have been complicated by cross-reactivity in T cells assays. These findings can now be re-evaluated in the light of novel technologies to identify serotype-specific T cell responses. (C) 2013 Elsevier B. V. All rights reserved.
引用
收藏
页码:605 / 611
页数:7
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