Morphological alteration of fibroblasts mechanically stressed in a collagen lattice

被引：6

作者：

Chamson, A ^{[1
]}

Sudre, F ^{[1
]}

LeGuen, C ^{[1
]}

Le, J ^{[1
]}

Rattner, A ^{[1
]}

Frey, J ^{[1
]}

机构：

[1] FAC MED, BIOCHIM LAB, F-42023 ST ETIENNE 2, FRANCE

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1997年 / 289卷 / 10期

关键词：

collagen lattice; fibroblasts; mechanical stress; lamellar bodies;

D O I：

10.1007/s004030050245

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The behavior of fibroblast-populated collagen lattices under mechanical stress was studied, Lattice retraction was blocked to allow the application of mechanical stress by contraction of the fibroblasts against the fixed ends of the lattice, The forces were modulated by varying the collagen/fibroblast ratio and the amount of collagen fibrils produced, by which the forces were transmitted, Transmission electron microscopy showed several disturbances of fibroblast ultrastructure, with empty and full vacuoles, lamellar bodies and signs of cytolysis. It is suggested that the morphological alterations in the fibroblasts map constitute a feedback reaction to the mechanical stress.

引用

页码：596 / 599

页数：4

共 12 条

[1] PRODUCTION OF A TISSUE-LIKE STRUCTURE BY CONTRACTION OF COLLAGEN LATTICES BY HUMAN-FIBROBLASTS OF DIFFERENT PROLIFERATIVE POTENTIAL INVITRO [J].