Hepatitis B and C viruses are not risks for pancreatic adenocarcinoma

被引:20
作者
Chang, Ming-Chu [1 ]
Chen, Chien-Hung [1 ]
Liang, Ja-Der [1 ]
Tien, Yu-Wen [2 ]
Hsu, Chiun [3 ]
Wong, Jau-Min [1 ]
Chang, Yu-Ting [1 ]
机构
[1] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Internal Med, Coll Med, Taipei 101, Taiwan
[2] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Surg, Coll Med, Taipei 101, Taiwan
[3] Natl Taiwan Univ, Coll Med, Grad Inst Oncol, Taipei 101, Taiwan
关键词
Hepatitis B virus; Hepatitis C virus; Pancreatic ductal adenocarcinoma; Risk; Endemic disease; Diabetes mellitus; HEPATOCELLULAR-CARCINOMA; VACCINATION PROGRAM; CANCER; INFECTION; TAIWAN; SEROPREVALENCE; EPIDEMIOLOGY; INDIVIDUALS; ASSOCIATION; CHINA;
D O I
10.3748/wjg.v20.i17.5060
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To investigate whether hepatitis B virus (HBV) and hepatitis C virus (HCV) increase risk of pancreatic ductal adenocarcinoma (PDAC). METHODS: We recruited 585 patients with cytological and/or pathologically confirmed PDAC in National Taiwan University Hospital from September 2000 to September 2013, and 1716 age-, sex-, and race-matched controls who received a screening program in a community located in Northern Taiwan. Blood samples were tested for the presence of HCV antibodies (anti-HCV), HBV surface antigen (HBsAg), antibodies against HBsAg (anti-HBs), and hepatitis B core antigen (anti-HBc) in all cases and controls. The odds ratio (OR) of PDAC was estimated by logistic regression analysis with adjustment diabetes mellitus (DM) and smoking. RESULTS: HBsAg was positive in 73 cases (12.5%) and 213 controls (12.4%). Anti-HCV was positive in 22 cases (3.8%) and 45 controls (2.6%). Anti-HBs was positive in 338 cases (57.8%) and 1047 controls (61.0%). The estimated ORs of PDAC in multivariate analysis were as follows: DM, 2.08 (95% CI: 1.56-2.76, P < 0.001), smoking, 1.36 (95% CI: 1.02-1.80, P = 0.035), HBsAg(+)/anti-HBc(+)/anti-HBs(-), 0.89 (95% CI: 0.89-1.68, P = 0.219), HBsAg(-)/anti-HBc(+)/anti-HBs(+), 1.03 (95% CI: 0.84-1.25, P = 0.802). CONCLUSION: HBV and HCV infection are not associated with risk of PDCA after adjustment for age, sex, DM and smoking, which were independent risk factors of PDAC. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
引用
收藏
页码:5060 / 5065
页数:6
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