Interference of amino acid patterns and tissue-specific amino acids absorption dominance under the influence of tumor cell protein degradation toxins

The excessively rapid degradation of proteins leads to an excess of amino acids which causes an impairment of the functions of normal cells of the tumor-bearing host specifically programmed amino acids absorption dominance which is of existential importance for tumor cells. This mechanism can be considered the result of the initiating effect of a protein degradation toxin (PDT) secreted from tumor cells. This is not only capable of attacking body protein, but also of attacking cells of another tumor. According to clinical observations, changes in biochemical processes which counteract the formation of an excess of amino acids indicate a tumor-repressive effect and can form the basis for the development of appropriate therapy concepts. (C) 1999 Harcourt Publishers Ltd.