Mapping of RNA-protein interactions

被引：15
作者：
Gopinath, Subash Chandra Bose [1 ]
机构：
[1] Natl Inst Adv Ind Sci & Technol, Ctr Appl Near Field Opt Res, Inst Biol Resources & Funct, Tsukuba, Ibaraki 3058562, Japan
来源：
ANALYTICA CHIMICA ACTA | 2009年 / 636卷 / 02期
关键词：
Ribonucleic acid; Ribonucleic acid-aptamer; Ribonucleic acid-protein; Mapping; HEPATITIS-C-VIRUS; HIGH-AFFINITY BINDING; IN-VITRO SELECTION; HIV-1 NUCLEOCAPSID PROTEIN; PRIMER EXTENSION ANALYSIS; ENDOTHELIAL GROWTH-FACTOR; MESSENGER-RNA; NUCLEIC-ACID; ESCHERICHIA-COLI; IMMUNODEFICIENCY-VIRUS;
D O I：
10.1016/j.aca.2009.01.052
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
RNA-protein interactions are important biological events that perform multiple functions in all living organisms. The wide range of RNA interactions demands diverse conformations to provide contacts for the selective recognition of proteins. Various analytical procedures are presently available for quantitative analyses of RNA-protein complexes, but analytical-based mapping of these complexes is essential to probe specific interactions. In this overview, interactions of functional RNAs and RNA-aptamers with target proteins are discussed by means of mapping strategies. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：117 / 128
页数：12
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