Serine proteases affecting blood coagulation and fibrinolysis from snake venoms

被引：130
作者：
Kini, R. Manjunatha
机构：
[1] Natl Univ Singapore, Dept Biol Sci, Prot Sci Lab, Fac Sci, Singapore 117543, Singapore
[2] Virginia Commonwealth Univ, Dept Biochem, Med Ctr, Richmond, VA USA
来源：
PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS | 2005年 / 34卷 / 4-5期
关键词：
procoagulant; anticoagulant; thrombin-like enzyme; protein C activator; factor V activator; prothrombin activator; plasminogen activator;
D O I：
10.1159/000092424
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Snake venom proteases, in addition to their contribution to the digestion of the prey, affect various physiological functions. They affect platelet aggregation, blood coagulation, fibrinolysis, complement system, blood pressure and nervous system. This review provides a ready reference for serine proteases that interfere in blood coagulation and fibrinolysis. They exhibit their activity by activation of specific zymogens of coagulation factors. These serine proteases serve as tools to study molecular details in the activation of specific factors involved in coagulation and fibrinolytic cascades and are useful in treating various thrombotic and hemostatic conditions. Copyright (c) 2005 S. Karger AG, Basel.
引用
收藏
页码：200 / 204
页数：5
相关论文
共 68 条
[11]   ACTION OF SNAKE-VENOM COMPONENTS ON THE HEMOSTATIC SYSTEM [J].
HUTTON, RA ;
WARRELL, DA .
BLOOD REVIEWS, 1993, 7 (03) :176-189
[12]   COAGULANT ACITIVITY OF TIGER SNAKE (NOTECHIS SCUTATUS SCUTATUS) VENOM [J].
JOBIN, F ;
ESNOUF, MP .
NATURE, 1966, 211 (5051) :873-+
[13]  
Joseph Jeremiah S., 2004, Current Drug Targets - Cardiovascular & Haematological Disorders, V4, P397, DOI 10.2174/1568006043335781
[14]   Amino acid sequence of trocarin, a prothrombin activator from Tropidechis carinatus venom:: Its structural similarity to coagulation factor Xa [J].
Joseph, JS ;
Chung, MCM ;
Jeyaseelan, K ;
Kini, RM .
BLOOD, 1999, 94 (02) :621-631
[15]   The intriguing world of prothrombin activators from snake venom [J].
Kini, RM .
TOXICON, 2005, 45 (08) :1133-1145
[16]   Structure-function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms [J].
Kini, RM .
TOXICON, 2005, 45 (08) :1147-1161
[17]  
Kini RM, 2001, THROMB HAEMOSTASIS, V86, P710
[18]  
KINI RM, PERSPECTIVES MOL TOX, P341
[19]   ISOLATION OF A PROTEIN C ACTIVATOR FROM SOUTHERN COPPERHEAD VENOM [J].
KISIEL, W ;
CHOI, E ;
KONDO, S .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 143 (03) :917-922
[20]  
KISIEL W, 1987, J BIOL CHEM, V262, P12607
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