This paper presents a novel methodology in planning the PN-offsets of a highly non-uniform CDMA network and discusses the major related issues. The strategy is applicable to any real life PCS and cellular networks. It is shown that by optimally choosing/arranging parameters, it is not only possible to mitigate the co- and adjacent PN-offset interferences, sufficient PN-offset values can also be reserved for new cells to be added into existing clusters for future network development.