LaPSvS1, a (1→3)-β-galactan sulfate and its effect on angiogenesis in vivo and in vitro

被引：54

作者：

Bürgermeister, J

Paper, DH

Vogl, H

Linhardt, RJ

Franz, G

机构：

[1] Univ Regensburg, Inst Pharmaceut Biol, D-93040 Regensburg, Germany

[2] Univ Iowa, Dept Chem, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA

[3] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA

来源：

CARBOHYDRATE RESEARCH | 2002年 / 337卷 / 16期

关键词：

angiogenesis inhibitor; antiinflammatory; CAM-assay; FGF-2; (1 -> 3)-beta-galactan-sulfate;

D O I：

10.1016/S0008-6215(02)00163-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LaPSvS1, a highly sulfated branched (1 --> 3)-beta-galactan was prepared from the arabino-galactan from Larix decidua Miller by partial hydrolysis and subsequent sulfation with SO3-pyridine in DMF. The molecular weight was analyzed by GPC and the sulfate content was determined by ion chromatography. LaPSvS1 exhibited good antiangiogenic and antiinflammatory effects in two different modifications of the known CAM-assay. In vitro results obtained in the FGF-2-trypsin-assay and in fluorospectrometric experiments revealed that LaPSvS1 interacts with the fibroblast growth factor 2 system. This interaction is correlated with the in vivo effect of LaPSvS1 on FGF-2 induced angiogenesis. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1459 / 1466

页数：8

共 29 条

[1] Tumor angiogenesis - new drugs on the block [J].