Circulating Tumor Cells: From Theory to Nanotechnology-Based Detection

被引:43
作者
Ming, Yue [1 ]
Li, Yuanyuan [1 ]
Xing, Haiyan [1 ]
Luo, Minghe [1 ]
Li, Ziwei
Chen, Jianhong [1 ]
Mo, Jingxin [2 ,3 ]
Shi, Sanjun [1 ]
机构
[1] Third Mil Med Univ, Daping Hosp, Inst Surg Res, Dept Pharm, Chongqing, Peoples R China
[2] Sun Yat Sen Univ, Minist Educ, Key Lab Stem Cells & Tissue Engn, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Histol & Embryol, Guangzhou, Guangdong, Peoples R China
关键词
cancer stem cells; stem-cell properties; circulating tumor cells; metastasis; nanotechnology; CTC isolation and detection; BREAST-CANCER PATIENTS; EPITHELIAL-MESENCHYMAL TRANSITION; STEM-CELLS; EFFICIENT CAPTURE; PERIPHERAL-BLOOD; CLINICAL-SIGNIFICANCE; EXPRESSION; METASTASIS; ENRICHMENT; SURVIVAL;
D O I
10.3389/fphar.2017.00035
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cancer stem cells with stem-cell properties are regarded as tumor initiating cells. Sharing stem-cell properties, circulating tumor cells (CTCs) are responsible for the development of metastasis, which significant affects CTC analysis in clinical practice. Due to their extremely low occurrence in blood, however, it is challenging to enumerate and analyze CTCs. Nanotechnology is able to address the problems of insufficient capture efficiency and low purity of CTCs owing to the unique structural and functional properties of nanomaterials, showing strong promise for CTC isolation and detection. In this review, we discuss the role of stem-like CTCs in metastases, provide insight into recent progress in CTC isolation and detection approaches using various nanoplatforms, and highlight the role of nanotechnology in the advancement of CTC research.
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页数:11
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