Intrauterine Closure of the Ductus Arteriosus: Implications for the Neonatologist

被引:6
作者
Aslam, Muhammad [1 ,2 ,3 ]
Christou, Helen A. [1 ,2 ,3 ]
机构
[1] Childrens Hosp, Neonatal Intens Care Units, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
关键词
Ductus arteriosus; congestive heart failure; pulmonary hypertension; fetal hydrops; prostaglandins; IN-VIVO; EXPRESSION; INDOMETHACIN; CONSTRICTION; EP4; MICE; RAT;
D O I
10.1055/s-0029-1214247
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Intrauterine closure of the fetal ductus arteriosus is a rare but serious condition. It can lead to congestive heart failure, fetal hydrops, and fetal death. No intrauterine intervention is currently available to treat this condition. Postnatally, it can present as pulmonary hypertension and can be associated with high mortality and morbidity. Postnatal therapies aimed at pulmonary hypertension or with medications that maintain the patency of the ductus arteriosus arc variably successful. We present the neonatal course of a full-term neonate with severe pulmonary hypertension and intrauterine closure of the ductus arteriosus who survived to early infancy.
引用
收藏
页码:473 / 478
页数:6
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