NAD to the rescue

被引：38

作者：

Bedalov, A ^{[1
]}

Simon, JA

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[2] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA

来源：

SCIENCE | 2004年 / 305卷 / 5686期

关键词：

D O I：

10.1126/science.1102497

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：954 / 955

页数：2

共 13 条

[1] Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels [J].

Anderson, RM ;

Bitterman, KJ ;

Wood, JG ;

Medvedik, O ;

Cohen, H ;

Lin, SS ;

Manchester, JK ;

Gordon, JI ;

Sinclair, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (21) :18881-18890

[2] Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration [J].

Araki, T ;

Sasaki, Y ;

Milbrandt, J .

SCIENCE, 2004, 305 (5686) :1010-1013

[3] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].

Brunet, A ;

Sweeney, LB ;

Sturgill, JF ;

Chua, KF ;

Greer, PL ;

Lin, YX ;

Tran, H ;

Ross, SE ;

Mostoslavsky, R ;

Cohen, HY ;

Hu, LS ;

Cheng, HL ;

Jedrychowski, MP ;

Gygi, SP ;

Sinclair, DA ;

Alt, FW ;

Greenberg, ME .

SCIENCE, 2004, 303 (5666) :2011-2015

[4] Axon pathology in neurological disease: a neglected therapeutic target [J].

Coleman, MP ;

Perry, VH .

TRENDS IN NEUROSCIENCES, 2002, 25 (10) :532-537

[5] ABSENCE OF WALLERIAN DEGENERATION DOES NOT HINDER REGENERATION IN PERIPHERAL-NERVE [J].

LUNN, ER ;

PERRY, VH ;

BROWN, MC ;

ROSEN, H ;

GORDON, S .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1989, 1 (01) :27-33

[6] Negative control of p53 by Sir2α promotes cell survival under stress [J].

Luo, JY ;

Nikolaev, AY ;

Imai, S ;

Chen, DL ;

Su, F ;

Shiloh, A ;

Guarente, L ;

Gu, W .

CELL, 2001, 107 (02) :137-148

[7] Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene [J].

Mack, TGA ;

Reiner, M ;

Beirowski, B ;

Mi, WQ ;

Emanuelli, M ;

Wagner, D ;

Thomson, D ;

Gillingwater, T ;

Court, F ;

Conforti, L ;

Fernando, FS ;

Tarlton, A ;

Andressen, C ;

Addicks, K ;

Magni, G ;

Ribchester, RR ;

Perry, VH ;

Coleman, MP .

NATURE NEUROSCIENCE, 2001, 4 (12) :1199-1206

[8] Mammalian SIRT1 represses forkhead transcription factors [J].

Motta, MC ;

Divecha, N ;

Lemieux, M ;

Kamel, C ;

Chen, D ;

Gu, W ;

Bultsma, Y ;

McBurney, M ;

Guarente, L .

CELL, 2004, 116 (04) :551-563

[9]

SADAJI A, 2004, CURR BIOL, V14, P326

[10] hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase [J].

Vaziri, H ;

Dessain, SK ;

Eagon, EN ;

Imai, SI ;

Frye, RA ;

Pandita, TK ;

Guarente, L ;

Weinberg, RA .

CELL, 2001, 107 (02) :149-159

← 1 2 →