Structural and functional characteristics of S1P receptors

被引：409

作者：

Sanchez, T ^{[1
]}

Hla, T ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Ctr Vasc Biol, Dept Cell Biol, Farmington, CT 06030 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2004年 / 92卷 / 05期

关键词：

Rho GTPases; migration; vascular maturation; vascular permeability; sphingosine kinase;

D O I：

10.1002/jcb.20127

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sphingosine-1-phosphate (SIP) family of G protein-coupled receptors (GPCR) regulates essential cellular processes Such as proliferation, migration, cytoskeletal organization, adherens junction assembly, and morphogenesis. SIP, a product from the breakdown of sphingomyelin, binds to the five members of this receptor family, S1P(1), S1P(2), S1P(3), S1P(4), and S1P(5), previously referred to as endothelial differentiation gene (EDG)-1, -5, -3, -6, and -8. SIP receptors are widely expressed in different tissues, so it is not surprising that the SI P receptor family regulates many physiological processes, such as vascular maturation, cardiac development, lymphocyte trafficking, and vascular permeability. FTY720, a new S1P receptor agonist, is undergoing clinical trials as an immunosuppressor. Understanding the physiological role of these receptors and the basics of the ligand-receptor interaction will potentially provide new therapies to control a variety of diseases. (C) 2004 Wiley-Liss, Inc.

引用

页码：913 / 922

页数：10

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