Cardiac troponins

被引：63
作者：
Sarko, J
Pollack, CV
机构：
[1] Maricopa Cty Gen Hosp, Dept Emergency Med, Phoenix, AZ 85008 USA
[2] Penn Hosp, Dept Emergency Med, Philadelphia, PA USA
来源：
JOURNAL OF EMERGENCY MEDICINE | 2002年 / 23卷 / 01期
关键词：
troponin; cardiology; chest pain risk stratification; acute coronary syndrome; assay;
D O I：
10.1016/S0736-4679(02)00463-8
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Cardiac troponins I and T are proteins integral to the function of cardiac muscle. They are very sensitive markers for the detection of myocardial damage, and the ability to assay their serum levels accurately and quickly have revolutionized the concepts of minor myocardial injury and infarction. They are also powerful prognostic indicators of future adverse cardiac events. Limitations, more of troponin T than I, include decreased specificity in renal failure and skeletal muscle disease. Rapid, whole blood assays are now available that can be done at the patient's bedside. This review discusses the cardiac troponins, their biochemistry, the assays for them currently available, and their roles in the evaluation of cardiac disease in the Emergency Department (ED). (C) 2002 Elsevier Science Inc.
引用
收藏
页码：57 / 65
页数：9
相关论文
共 111 条
  • [11] Baxter MS, 1997, ACAD EMERG MED, V4, P1018
  • [12] Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma
    Bertinchant, JP
    Polge, A
    Mohty, D
    Nguyen-Ngoc-Lam, R
    Estorc, J
    Cohendy, R
    Joubert, P
    Poupard, P
    Fabbro-Peray, P
    Monpeyroux, F
    Poirey, S
    Ledermann, B
    Raczka, F
    Brunet, J
    Nigond, J
    de la Coussaye, JE
    [J]. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2000, 48 (05) : 924 - 931
  • [13] BHAYANA V, 1995, CLIN CHEM, V41, P312
  • [14] Bleier J, 1998, CLIN CHEM, V44, P1912
  • [15] Bodor GS, 1997, CLIN CHEM, V43, P476
  • [16] BODOR GS, 1995, CLIN CHEM, V41, P1710
  • [17] Serum cardiac troponin I and ST-segment elevation in patients with acute pericarditis
    Bonnefoy, E
    Godon, P
    Kirkorian, G
    Fatemi, M
    Chevalier, P
    Touboul, P
    [J]. EUROPEAN HEART JOURNAL, 2000, 21 (10) : 832 - 836
  • [18] ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: Executive summary and recommendations - A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina)
    Braunwald, E
    Antman, EM
    Beasley, JW
    Califf, RM
    Cheitlin, MD
    Hochman, JS
    Jones, RH
    Kereiakes, D
    Kupersmith, J
    Levin, TN
    Pepine, CJ
    Schaeffer, JW
    Smith, EE
    Steward, DE
    Theroux, P
    Gibbons, RJ
    Alpert, JS
    Eagle, KA
    Faxon, DP
    Fuster, V
    Gardner, TJ
    Gregoratos, G
    Russell, RO
    Smith, SC
    [J]. CIRCULATION, 2000, 102 (10) : 1193 - 1209
  • [19] Prognostic implications of detection of troponin I patients with unstable angina pectoris
    Brscic, E
    Chiappino, I
    Bergerone, S
    Lanfranco, G
    Mainardi, L
    Imazio, M
    Amellone, C
    Pagni, R
    Rosettani, E
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1998, 82 (08) : 971 - +
  • [20] TROPONIN-T AS A MARKER OF ISCHEMIC MYOCARDIAL INJURY
    BURLINA, A
    ZANINOTTO, M
    SECCHIERO, S
    RUBIN, D
    ACCORSI, F
    [J]. CLINICAL BIOCHEMISTRY, 1994, 27 (02) : 113 - 121
12345678910