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Feedback-Related Brain Potentials Indicate the Influence of Craving on Decision-Making in Patients with Alcohol Use Disorder: An Experimental Study
被引：4
|作者：
Sehrig, Sarah
[1
]
Odenwald, Michael
[1
]
Rockstroh, Brigitte
[1
]
机构：
[1] Univ Konstanz, Dept Psychol, Univ Str 10, DE-78457 Constance, Germany
关键词：
Alcohol craving;
Event-related potential;
Alcohol use disorder;
Reward;
Feedback;
MEDIAL FRONTAL-CORTEX;
RISK-TAKING;
REWARD ANTICIPATION;
NEGATIVITY;
ADDICTION;
DOPAMINE;
ACTIVATION;
MECHANISMS;
PICTURES;
DEFICITS;
D O I：
10.1159/000511417
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Introduction: Alcohol craving is a key symptom of alcohol use disorder (AUD) and a significant cause of poor treatment outcome and frequent relapse. Craving is supposed to impair executive functions by modulating reward salience and decision-making. Objective: The present study sought to clarify this modulation by scrutinizing reward feedback processing in an experimental decision-making task, which was accomplished by AUD patients in 2 conditions, in the context of induced alcohol craving and in neutral context. Methods: AUD inpatients (N = 40) accomplished the Balloon Analog Risk Task, while their EEG was monitored; counterbalanced across conditions, the tasks were preceded either by craving induction by means of imagery and olfactory alcohol cues, or by neutral cues. Decision choice and variability, and event-related potentials (ERPs) prior to (stimulus-preceding negativity [SPN]) and following (P2a) reward feedback upon decisions, and the outcome-related feedback-related negativity (FRN) were compared between conditions and between patients, who experienced high craving upon alcohol cues (N = 18) and those who did not (N = 22). Results: Upon craving induction (vs. neutral condition), high-craving AUD patients showed less adjustment of decision choice to preceding reward experience and more variable decisions than low-craving AUD patients, together with accentuated reward-associated ERP (SPN and P2a), while outcome-related FRN was not modified by craving. Conclusions: Results support orientation to reward in AUD patients, particularly amplified upon experienced craving, which may interfere with (feedback-guided) decision-making even in alcohol-unrelated context. Craving-accentuated ERP indices suggest neuroadaptive changes of cognitive-motivational states upon chronic alcohol abuse. Together with altered reward-related expectancies, this has to be considered in intervention and relapse prevention.
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页码：216 / 226
页数：11
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