Impact of cigarette smoking in type 2 diabetes development

被引：81

作者：

Xie, Xi-tao ^{[2
]}

Liu, Qiang ^{[3
]}

Wu, Jie ^{[3
]}

Wakui, Makoto ^{[1
]}

机构：

[1] Hirosaki Natl Hosp, Div Clin Res, Hirosaki, Aomori 0368545, Japan

[2] Arizona State Univ, Ctr Metab Biol, Tempe, AZ 85287 USA

[3] Barrow Neurol Inst, Div Neurol, Phoenix, AZ 85013 USA

来源：

ACTA PHARMACOLOGICA SINICA | 2009年 / 30卷 / 06期

关键词：

smoking; diabetes; nicotinic receptor; BETA-CELL APOPTOSIS; NICOTINIC RECEPTORS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; NEONATAL EXPOSURE; OXIDATIVE STRESS; VASCULAR-DISEASE; RISK-FACTORS; FETAL; HYPERGLYCEMIA;

D O I：

10.1038/aps.2009.49

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Many patients with type 2 diabetes mellitus (DM2) are at risk for micro and macro vascular complications, which could be observed in heavy smokers. Cigarette smoking increases the risk for type 2 diabetes incidence. Nicotine, acknowledged as the major pharmacologically active chemical in tobacco, is responsible for the association between cigarette smoking and development of diabetes. This minireview summarized recent studies on nicotine effects on insulin action and insulin secretion, indicating the impact of nicotine on type 2 diabetes development.

引用

页码：784 / 787

页数：4

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