Olfactory disorders and general pathologies.: Analysis and literature review.

被引:9
|
作者
Norès, JM [1 ]
Biacabe, B [1 ]
Bonfils, P [1 ]
机构
[1] Univ Paris 05, Hop Raymond Poincare, Serv Med Interne, F-92380 Garches, France
来源
REVUE DE MEDECINE INTERNE | 2000年 / 21卷 / 01期
关键词
general pathologies; olfactory disorders;
D O I
10.1016/S0248-8663(00)87235-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction. - Disturbances of the sense of smell have been documented in many general pathologies. The actual etiology of such impairments is often difficult to determine. The aim of the authors is to review the literature on olfactory disorders in general diseases. Current knowledge and key points. - Acute and chronic liver disorders are frequently associated with hyposmia, which can be improved by vitamin A intake. Renal insufficiency could induce hyposmia according to the severity of the renal disease. Olfactory disorders seem to regress after transplantation but not after dialysis. Patients with AIDS - especially neurological forms - often present with taste and smell impairments. Smell alteration can also be noted in hypothyroidism and pseudo-hypoparathyroidism. In addition, taste and smell impairments have been described in patients with adrenal insufficiency or Cushing's disease. Subsequent to glucocorticoid therapy adrenal insufficiency can induce regressive olfactory hypersensitivity. Olfactory impairments in diabetic patients can be associated with diabetic macrovascular manifestations due to ischemic alterations in the olfactory neuroepithelium. Impairment of the sense of smell has been described in many systemic diseases such as Horton's arteritis and Sjogren's syndrome. Future prospects and projects. - Olfactory disorders should be investigated in patients presenting one of the above-mentioned diseases. (C) 2000 Editions medicales et scientifiques Elsevier SAS.
引用
收藏
页码:95 / 104
页数:10
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