Bioactive sesquiterpene lactones from Centaurea species and their cytotoxic/cytostatic activity against human cell lines in vitro

被引：61

作者：

Koukoulitsa, E

Skaltsa, H ^{[1
]}

Karioti, A

Demetzos, C

Dimas, K

机构：

[1] Univ Athens, Sch Pharm, Dept Pharmacognosy, Div Pharmacognosy, GR-15771 Athens, Greece

[2] St Savvas Hosp, Dept Biochem, Papanicolaou Res Ctr Oncol, Athens, Greece

来源：

PLANTA MEDICA | 2002年 / 68卷 / 07期

关键词：

D O I：

10.1055/s-2002-32893

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Sesquiterpene lactones isolated from the aerial parts of various species of the genus Centaurea were examined for their in vitro cytotoxic/cytostatic activity against five human cell lines (i.e., DLD1, SF268, MCF7, H460 and OVCAR3). Compounds 1-4 were isolated from C. zuccariniana, 5 and 6 from C achaia, 7 from C. thessala ssp. drakiensis and compounds 8 and 9 from C deusta. Compound 1, 8alpha-O-(3,4-dihydroxy-2-methylenebutanoyloxy)dehydromelitensine was found to be the most active, exhibited a considerable growth inhibiting activity against three of the cell lines tested, while compound 5 8a-O-(3-hydroxy-2-methylenepropanoyl)dehydromelitensin exhibited a growth inhibiting effect against most of the tested cell lines. A new eudesmanolide (8alpha-hydroxysonchucarpolide, 4) was isolated from C. zuccariniana and its structure was elucidated by spectroscopic methods.

引用

页码：649 / 652

页数：4

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