Global regulators and environmental adaptation in Gram-negative pathogens

被引：14

作者：

Dorman, C. J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Moyne Inst Prevent Med, Sch Genet & Microbiol, Dept Microbiol, Dublin 2, Ireland

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2009年 / 15卷

基金：

英国惠康基金; 爱尔兰科学基金会;

关键词：

DNA supercoiling; Escherichia coli; Fis; H-NS; nucleoid-associated protein; Salmonella enterica; serovar Typhimurium; ENTERICA SEROVAR TYPHIMURIUM; COMPLETE GENOME SEQUENCE; SALMONELLA-ENTERICA; GENE-EXPRESSION; H-NS; DNA; BACTERIA; PROTEINS; FIS;

D O I：

10.1111/j.1469-0691.2008.02684.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A powerful combination of single-gene studies and whole genome approaches has provided a wealth of information about the regulatory circuits used by bacteria to adapt to the environmental changes that are encountered during infection. The facultative intracellular pathogen Salmonella enterica will be used to illustrate how global regulators such as the nucleoid-associated proteins Fis and H-NS collaborate with fluctuations in the superhelicity of the DNA template to modify the gene expression profile of the bacterial cell outside and inside the host.

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收藏

页码：47 / 50

页数：4

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