Lewis acid-promoted addition of methylenecyclopropanes to aldehydes and ketones

被引:23
作者
Miura, K [1 ]
Takasumi, M [1 ]
Hondo, T [1 ]
Saito, H [1 ]
Hosomi, A [1 ]
机构
[1] UNIV TSUKUBA,DEPT CHEM,TSUKUBA,IBARAKI 305,JAPAN
关键词
D O I
10.1016/S0040-4039(97)00981-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
In the presence of TiCl4, methylenecyclopropane (1a) easily reacted with aliphatic aldehydes to give the beta-(chloromethyl)allylated products 2 in good yields along with a small amount of the methylenetetrahydrofurans 3. The reaction with chiral alpha- and beta-alkoxy aldehydes proceeded with high levels of chelation control. (C) 1997 Elsevier Science Ltd.
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页码:4587 / 4590
页数:4
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