Fibroblast Growth Factor 23 and αKlotho in Acute Kidney Injury: Current Status in Diagnostic and Therapeutic Applications

被引：10
作者：
Neyra, Javier A. [1 ,2 ,3 ]
Hu, Ming Chang [1 ,2 ]
Moe, Orson W. [1 ,2 ,4 ]
机构：
[1] Charles & Jane Pak Ctr Mineral Metab & Clin Res, Dallas, TX USA
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA
[3] Univ Kentucky, Dept Med, Div Nephrol Bone & Mineral Metab, Lexington, KY 40506 USA
[4] Univ Texas Southwestern Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA
来源：
NEPHRON | 2020年 / 144卷 / 12期
基金：
美国国家卫生研究院;
关键词：
Acute kidney injury; α Klotho; Biomarker; Chronic kidney disease; FGF23; Treatment; FGF23; EXPRESSION; PROGRESSION; DEATH; RISK; AKI; ACTIVATION; DISEASE; INTACT;
D O I：
10.1159/000509856
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Fibroblast growth factor (FGF) 23 and alpha Klotho are circulating mineral regulatory substances that also have a very diverse range of actions. Acute kidney injury (AKI) is a state of high FGF23 and low alpha Klotho. Clinical association data for FGF23 are strong, but the basic pathobiology of FGF23 in AKI is rather sparse. Conversely, preclinical data supporting a pathogenic role of alpha Klotho in AKI are strong, but the human data are still being generated. This pair of substances can potentially serve as diagnostic and prognostic biomarkers. FGF23 blockade and alpha Klotho restoration can have prophylactic and therapeutic utility in AKI. The literature to date is briefly reviewed in this article.
引用
收藏
页码：665 / 672
页数：8
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