Fibroblast Growth Factor 23 and αKlotho in Acute Kidney Injury: Current Status in Diagnostic and Therapeutic Applications

被引：10

作者：

Neyra, Javier A. ^{[1
,2
,3
]}

Hu, Ming Chang ^{[1
,2
]}

Moe, Orson W. ^{[1
,2
,4
]}

机构：

[1] Charles & Jane Pak Ctr Mineral Metab & Clin Res, Dallas, TX USA

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[3] Univ Kentucky, Dept Med, Div Nephrol Bone & Mineral Metab, Lexington, KY 40506 USA

[4] Univ Texas Southwestern Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA

来源：

NEPHRON | 2020年 / 144卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Acute kidney injury; α Klotho; Biomarker; Chronic kidney disease; FGF23; Treatment; FGF23; EXPRESSION; PROGRESSION; DEATH; RISK; AKI; ACTIVATION; DISEASE; INTACT;

D O I：

10.1159/000509856

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Fibroblast growth factor (FGF) 23 and alpha Klotho are circulating mineral regulatory substances that also have a very diverse range of actions. Acute kidney injury (AKI) is a state of high FGF23 and low alpha Klotho. Clinical association data for FGF23 are strong, but the basic pathobiology of FGF23 in AKI is rather sparse. Conversely, preclinical data supporting a pathogenic role of alpha Klotho in AKI are strong, but the human data are still being generated. This pair of substances can potentially serve as diagnostic and prognostic biomarkers. FGF23 blockade and alpha Klotho restoration can have prophylactic and therapeutic utility in AKI. The literature to date is briefly reviewed in this article.

引用

页码：665 / 672

页数：8

共 49 条

[1] Fibroblast Growth Factor 23 Inhibits Extrarenal Synthesis of 1,25-Dihydroxyvitamin D in Human Monocytes [J].

Bacchetta, Justine ;

Sea, Jessica L. ;

Chun, Rene F. ;

Lisse, Thomas S. ;

Wesseling-Perry, Katherine ;

Gales, Barbara ;

Adams, John S. ;

Salusky, Isidro B. ;

Hewison, Martin .

JOURNAL OF BONE AND MINERAL RESEARCH, 2013, 28 (01) :46-55

[2] Acute Kidney Injury and Risk of Incident Heart Failure Among US Veterans [J].

Bansal, Nisha ;

Matheny, Michael E. ;

Greevy, Robert A., Jr. ;

Eden, Svetlana K. ;

Perkins, Amy M. ;

Parr, Sharidan K. ;

Fly, James ;

Abdel-Kader, Khaled ;

Himmelfarb, Jonathan ;

Hung, Adriana M. ;

Speroff, Theodore ;

Ikizler, T. Alp ;

Siew, Edward D. .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2018, 71 (02) :236-245

[3] The severity of acute kidney injury predicts progression to chronic kidney disease [J].

Chawla, Lakhmir S. ;

Amdur, Richard L. ;

Amodeo, Susan ;

Kimmel, Paul L. ;

Palant, Carlos E. .

KIDNEY INTERNATIONAL, 2011, 79 (12) :1361-1369

[4] Fibroblast Growth Factor 23 and Klotho in AKI [J].

Christov, Marta ;

Neyra, Javier A. ;

Gupta, Sanjeev ;

Leaf, David E. .

SEMINARS IN NEPHROLOGY, 2019, 39 (01) :57-75

[5] Plasma FGF23 levels increase rapidly after acute kidney injury [J].

Christov, Marta ;

Waikar, Sushrut S. ;

Pereira, Renata C. ;

Havasi, Andrea ;

Leaf, David E. ;

Goltzman, David ;

Pajevic, Paola D. ;

Wolf, Myles ;

Jueppner, Harald .

KIDNEY INTERNATIONAL, 2013, 84 (04) :776-785

[6] Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis [J].

Coca, Steven G. ;

Singanamala, Swathi ;

Parikh, Chirag R. .

KIDNEY INTERNATIONAL, 2012, 81 (05) :442-448

[7] Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice [J].

Doi, Shigehiro ;

Zou, Yonglong ;

Togao, Osamu ;

Pastor, Johanne V. ;

John, George B. ;

Wang, Lei ;

Shiizaki, Kazuhiro ;

Gotschall, Russell ;

Schiavi, Susan ;

Yorioka, Noriaki ;

Takahashi, Masaya ;

Boothman, David A. ;

Kuro-o, Makoto .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (10) :8655-8665

[8] FGF23 at the crossroads of phosphate, iron economy and erythropoiesis [J].

Edmonston, Daniel ;

Wolf, Myles .

NATURE REVIEWS NEPHROLOGY, 2020, 16 (01) :7-19

[9] FGF23 induces left ventricular hypertrophy [J].

Faul, Christian ;

Amaral, Ansel P. ;

Oskouei, Behzad ;

Hu, Ming-Chang ;

Sloan, Alexis ;

Isakova, Tamara ;

Gutierrez, Orlando M. ;

Aguillon-Prada, Robier ;

Lincoln, Joy ;

Hare, Joshua M. ;

Mundel, Peter ;

Morales, Azorides ;

Scialla, Julia ;

Fischer, Michael ;

Soliman, Elsayed Z. ;

Chen, Jing ;

Go, Alan S. ;

Rosas, Sylvia E. ;

Nessel, Lisa ;

Townsend, Raymond R. ;

Feldman, Harold I. ;

Sutton, Martin St. John ;

Ojo, Akinlolu ;

Gadegbeku, Crystal ;

Di Marco, Giovana Seno ;

Reuter, Stefan ;

Kentrup, Dominik ;

Tiemann, Klaus ;

Brand, Marcus ;

Hill, Joseph A. ;

Moe, Orson W. ;

Kuro-o, Makoto ;

Kusek, John W. ;

Keane, Martin G. ;

Wolf, Myles .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (11) :4393-4408

[10] Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation [J].

Goetz, Regina ;

Nakada, Yuji ;

Hu, Ming Chang ;

Kurosu, Hiroshi ;

Wang, Lei ;

Nakatani, Teruyo ;

Shi, Mingjun ;

Eliseenkova, Anna V. ;

Razzaque, Mohammed S. ;

Moe, Orson W. ;

Kuro-o, Makoto ;

Mohammadi, Moosa .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (01) :407-412

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