Protein kinase Cδ mutations may contribute to lupus through effects on T cells: comment on the article by Belot et al

被引：1
作者：
Richardson, Bruce [1 ]
Strickland, Faith M. [1 ]
Sawalha, Amr H. [1 ]
Gorelik, Gabriela [1 ]
机构：
[1] Univ Michigan, Ann Arbor, MI 48109 USA
来源：
ARTHRITIS & RHEUMATOLOGY | 2014年 / 66卷 / 01期
关键词：
DISEASE; OVEREXPRESSION; PROCAINAMIDE; HYDRALAZINE; MECHANISMS; EXPRESSION; GENES; MODEL;
D O I：
10.1002/art.38235
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：228 / 229
页数：3
相关论文
共 11 条
  • [1] Protein Kinase C Deficiency Causes Mendelian Systemic Lupus Erythematosus With B Cell-Defective Apoptosis and Hyperproliferation
    Belot, Alexandre
    Kasher, Paul R.
    Trotter, Eleanor W.
    Foray, Anne-Perrine
    Debaud, Anne-Laure
    Rice, Gillian I.
    Szynkiewicz, Marcin
    Zabot, Marie-Therese
    Rouvet, Isabelle
    Bhaskar, Sanjeev S.
    Daly, Sarah B.
    Dickerson, Jonathan E.
    Mayer, Josephine
    O'Sullivan, James
    Juillard, Laurent
    Urquhart, Jill E.
    Fawdar, Shameem
    Marusiak, Anna A.
    Stephenson, Natalie
    Waszkowycz, Bohdan
    W. Beresford, Michael
    Biesecker, Leslie G.
    C. M. Black, Graeme
    Rene, Celine
    Eliaou, Jean-Francois
    Fabien, Nicole
    Ranchin, Bruno
    Cochat, Pierre
    Gaffney, Patrick M.
    Rozenberg, Flore
    Lebon, Pierre
    Malcus, Christophe
    Crow, Yanick J.
    Brognard, John
    Bonnefoy, Nathalie
    [J]. ARTHRITIS AND RHEUMATISM, 2013, 65 (08): : 2161 - 2171
  • [2] Impaired T cell protein kinase Cδ activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus
    Gorelik, Gabriela
    Fang, Jing Yuan
    Wu, Ailing
    Sawalha, Amr H.
    Richardson, Bruce
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 179 (08) : 5553 - 5563
  • [3] Key role of ERK pathway signaling in lupus
    Gorelik, Gabriela
    Richardson, Bruce
    [J]. AUTOIMMUNITY, 2010, 43 (01) : 17 - 22
  • [4] Protein Kinase Cδ Oxidation Contributes to ERK Inactivation in Lupus T Cells
    Gorelik, Gabriela J.
    Yarlagadda, Sushma
    Richardson, Bruce C.
    [J]. ARTHRITIS AND RHEUMATISM, 2012, 64 (09): : 2964 - 2974
  • [5] Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ
    Miyamoto, A
    Nakayama, K
    Imaki, H
    Hirose, S
    Jiang, Y
    Abe, M
    Tsukiyama, T
    Nagahama, H
    Ohno, S
    Hatakeyama, S
    Nakayama, KI
    [J]. NATURE, 2002, 416 (6883) : 865 - 869
  • [6] Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors
    Oelke, K
    Lu, QJ
    Richardson, D
    Wu, AL
    Deng, C
    Hanash, S
    Richardson, B
    [J]. ARTHRITIS AND RHEUMATISM, 2004, 50 (06): : 1850 - 1860
  • [7] TREATING ACTIVATED CD4+ T-CELLS WITH EITHER OF 2 DISTINCT DNA METHYLTRANSFERASE INHIBITORS, 5-AZACYTIDINE OR PROCAINAMIDE, IS SUFFICIENT TO CAUSE A LUPUS-LIKE DISEASE IN SYNGENEIC MICE
    QUDDUS, J
    JOHNSON, KJ
    GAVALCHIN, J
    AMENTO, EP
    CHRISP, CE
    YUNG, RL
    RICHARDSON, BC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (01) : 38 - 53
  • [8] Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients
    Sawalha, A. H.
    Jeffries, M.
    Webb, R.
    Lu, Q.
    Gorelik, G.
    Ray, D.
    Osban, J.
    Knowlton, N.
    Johnson, K.
    Richardson, B.
    [J]. GENES AND IMMUNITY, 2008, 9 (04) : 368 - 378
  • [9] Diet Influences Expression of Autoimmune-Associated Genes and Disease Severity by Epigenetic Mechanisms in a Transgenic Mouse Model of Lupus
    Strickland, Faith M.
    Hewagama, Anura
    Wu, Ailing
    Sawalha, Amr H.
    Delaney, Colin
    Hoeltzel, Mark F.
    Yung, Raymond
    Johnson, Kent
    Mickelson, Barbara
    Richardson, Bruce C.
    [J]. ARTHRITIS AND RHEUMATISM, 2013, 65 (07): : 1872 - 1881
  • [10] Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus
    Strickland, Faith M.
    Hewagama, Anura
    Lu, Qianjian
    Wu, Ailing
    Hinderer, Robert
    Webb, Ryan
    Johnson, Kent
    Sawalha, Amr H.
    Delaney, Colin
    Yung, Raymond
    Richardson, Bruce C.
    [J]. JOURNAL OF AUTOIMMUNITY, 2012, 38 (2-3) : J135 - J143
12