Muscimol as an Ionotropic GABA Receptor Agonist

被引：73
|
作者：
Johnston, Graham A. R. [1 ]
机构：
[1] Univ Sydney, Sch Med Sci Pharmacol, Adrien Albert Lab Med Chem, Sydney, NSW 2006, Australia
来源：
NEUROCHEMICAL RESEARCH | 2014年 / 39卷 / 10期
关键词：
GABA; Muscimol; GABA receptors; GABA transporters; GAMMA-AMINOBUTYRIC-ACID; RAT-BRAIN SLICES; NIPECOTIC ACID; THIP GABOXADOL; BINDING; INHIBITION; PHARMACOLOGY; BICUCULLINE; SERIES; ANTAGONIST;
D O I：
10.1007/s11064-014-1245-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe GABA receptors and was the lead compound in the development of a range of GABAergic agents including nipecotic acid, tiagabine, 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol, (Gaboxadol(A (R))) and 4-PIOL.
引用
收藏
页码：1942 / 1947
页数：6
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