Memory B-cells in healthy and anti body-deficient children

被引：35

作者：

Huck, Kirsten ^{[2
]}

Feyen, Oliver ^{[2
]}

Ghosh, Sujal ^{[2
]}

Beltz, Kathrin ^{[1
]}

Bellert, Sven ^{[2
]}

Niehues, Tim ^{[1
]}

机构：

[1] Univ Dusseldorf, Acad Hosp, HELIOS Klinikum Krefeld, Ctr Child & Adolescent Hlth, D-47805 Krefeld, Germany

[2] Univ Dusseldorf, Ctr Child & Adolescent Hlth, Dept Pediat Oncol Hematol & Clin Immunol, D-40225 Dusseldorf, Germany

来源：

CLINICAL IMMUNOLOGY | 2009年 / 131卷 / 01期

关键词：

B-cell subsets; Memory B-cells; Reference values; Common variable immunodeficiency; CVID; Children; Antibody deficiency; Hypogammaglobulinemia; COMMON VARIABLE IMMUNODEFICIENCY; IGA DEFICIENCY; ABNORMALITIES; DISEASE; TACI; SUBGROUPS; AGE;

D O I：

10.1016/j.clim.2008.11.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently it has become clear that a reduction of IgD-CD27+ memory B-cells in adult CVID patients correlates with clinical aspects of the disease. However, little is known about B-cell dysregulation in pediatric antibody deficiency. Reference values are essential for the interpretation of B-cell subpopulations in children. We present the clinical and immunophenotypical characterization of 16 children and adolescents with CVID and hypogammaglobulinemia. Reference values for IgD+CD27-, IgD+CD27+ and IgD-CD27+ B-cells in healthy children were established for five age groups. In healthy controls we found a continuous increase in IgD-CD27+ B-cell percentage with age from 1.35-5% of B-cells in the second year of life to 4.1-18.7% in adolescents. Interestingly, in 12/14 antibody-deficient patients memory B-cells are significantly below the age-related 10th percentile. We conclude that the reduction of memory B-cells is a useful additional marker for the detection of children with CVID hypogammaglobulinemia and may contribute to the early presentation. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：50 / 59

页数：10

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