Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3

被引：58

作者：

Perez-Alcazar, Marta ^{[1
,2
]}

Daborg, Jonny ^{[2
]}

Stokowska, Anna ^{[1
]}

Wasling, Pontus ^{[2
]}

Bjorefeldt, Andreas ^{[2
]}

Kalm, Marie ^{[1
]}

Zetterberg, Henrik ^{[3
,4
]}

Carlstrom, Karl E. ^{[5
,6
]}

Blomgren, Klas ^{[1
,7
,8
]}

Ekdahl, Christine T. ^{[5
,6
,9
]}

Hanse, Eric ^{[2
]}

Pekna, Marcela ^{[1
,10
]}

机构：

[1] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Dept Clin Neurosci & Rehabil, S-40530 Gothenburg, Sweden

[2] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Dept Physiol, S-40530 Gothenburg, Sweden

[3] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Dept Psychiat & Neurochem, S-43180 Molndal, Sweden

[4] UCL Inst Neurol, London WC1N 3BG, England

[5] Lund Univ, Div Clin Neurophysiol, Inflammat & Stem Cell Therapy Grp, SE-22184 Lund, Sweden

[6] Skane Univ Hosp, SE-22184 Lund, Sweden

[7] Univ Gothenburg, Queen Silvia Childrens Hosp, Dept Pediat Oncol, S-41345 Gothenburg, Sweden

[8] Karolinska Univ Hosp Q2 07, Karolinska Inst, Dept Womens & Childrens Hlth, S-17176 Stockholm, Sweden

[9] Lund Univ, Dept Clin Sci, Lund Epilepsy Ctr, SE-22184 Lund, Sweden

[10] Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3052, Australia

来源：

EXPERIMENTAL NEUROLOGY | 2014年 / 253卷

基金：

瑞典研究理事会;

关键词：

Complement cascade; Development; Epilepsy; Hippocampus; Synapse elimination; INHIBITORY SYNAPSES; STATUS EPILEPTICUS; ADULT; NEUROGENESIS; COMPLEMENT; MEMORY; IRRADIATION; IMPAIRMENT; MICROGLIA; YOUNG;

D O I：

10.1016/j.expneurol.2013.12.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous work implicated the complement system in adult neurogenesis as well as elimination of synapses in the developing and injured CNS. In the present study, we used mice lacking the third complement component (C3) to elucidate the role the complement system plays in hippocampus-dependent learning and synaptic function. We found that the constitutive absence of C3 is associated with enhanced place and reversal learning in adult mice. Our findings of lower release probability at CA3-CA1 glutamatergic synapses in combination with unaltered overall efficacy of these synapses in C3 deficient mice implicate 0 as a negative regulator of the number of functional glutamatergic synapses in the hippocampus. The C3 deficient mice showed no signs of spontaneous epileptiform activity in the hippocampus. We conclude that C3 plays a role in the regulation of the number and function of glutamatergic synapses in the hippocampus and exerts negative effects on hippocampus-dependent cognitive performance. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.

引用

页码：154 / 164

页数：11

共 44 条

[1] Decreased cytogenesis in the granule cell layer of the hippocampus and impaired place learning after irradiation of the young mouse brain evaluated using the IntelliCage platform [J].