The effects of vitamin B on the immune/cytokine network and their involvement in depression

被引：92

作者：

Mikkelsen, Kathleen ^{[1
]}

Stojanovska, Lily ^{[1
]}

Prakash, Monica ^{[1
]}

Apostolopoulos, Vasso ^{[1
]}

机构：

[1] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis, POB 14426, Melbourne, Vic 8001, Australia

来源：

MATURITAS | 2017年 / 96卷

关键词：

Inflammation; Immune system; Immune cells; Depression; Mental health; NECROSIS-FACTOR-ALPHA; KILLER-CELL ACTIVITY; FOLIC-ACID; ANTIINFLAMMATORY CYTOKINES; ANXIETY DISORDERS; MAJOR DEPRESSION; DOUBLE-BLIND; SERUM-LEVELS; SYMPTOMS; AMYGDALIN;

D O I：

10.1016/j.maturitas.2016.11.012

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-I, IL-6, TNF-alpha) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression. Hence, greater knowledge of how immune cells change in the presence of vitamin B derivatives could improve understanding of how immune changes may correlate with depression, all of which are discussed herein. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：58 / 71

页数：14

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