Circulating Tumor Cells: Diagnostic and Therapeutic Applications

被引：79
作者：
Lin, Eric [1 ,2 ,3 ]
Cao, Thong [4 ]
Nagrath, Sunitha [1 ,2 ,3 ]
King, Michael R. [4 ]
机构：
[1] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA
[4] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA
来源：
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 20 | 2018年 / 20卷
关键词：
circulating tumor cell; CTC; metastasis; microfluidics; TRAIL; tumor-draining lymph node; LABEL-FREE ISOLATION; PHOTOACOUSTIC FLOW-CYTOMETRY; METASTATIC BREAST-CANCER; TRAIL-COATED LEUKOCYTES; NATURAL-KILLER-CELLS; DRAINING LYMPH-NODE; DENDRITIC CELLS; PERIPHERAL-BLOOD; PANCREATIC-CANCER; MOLECULAR CHARACTERIZATION;
D O I：
10.1146/annurev-bioeng-062117-120947
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Metastasis contributes to poor prognosis in many types of cancer and is the leading cause of cancer-related deaths. Tumor cells metastasize to distant sites via the circulatory and lymphatic systems. In this review, we discuss the potential of circulating tumor cells for diagnosis and describe the experimental therapeutics that aim to target these disseminating cancer cells. We discuss the advantages and limitations of such strategies and how they may lead to the development of the next generation of antimetastasis treatments.
引用
收藏
页码：329 / 352
页数：24
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