Performance of 3 Rapid Tests for Discrimination Between HIV-1 and HIV-2 in Guinea-Bissau, West Africa

被引：33

作者：

Honge, Bo Langhoff ^{[1
,2
]}

Bjarnason Obinah, Magnus Petur ^{[1
,2
]}

Jespersen, Sanne ^{[1
,2
]}

Medina, Candida ^{[3
]}

da Silva Te, David ^{[3
]}

Jose da Silva, Zacarias ^{[2
,4
]}

Ostergaard, Lars ^{[1
]}

Lund Laursen, Alex ^{[1
]}

Wejse, Christian ^{[1
,2
,5
]}

Erikstrup, Christian ^{[6
]}

机构：

[1] Aarhus Univ Hosp, Dept Infect Dis, DK-8200 Aarhus, Denmark

[2] Indepth Network, Bandim Hlth Project, Bissau, Guinea Bissau

[3] Natl HIV Programme, Minist Hlth, Bissau, Guinea Bissau

[4] Natl Publ Hlth Lab, Bissau, Guinea Bissau

[5] Aarhus Univ, KGloHAU, Ctr Global Hlth, Sch Publ Hlth, Aarhus, Denmark

[6] Aarhus Univ Hosp, Dept Clin Immunol, DK-8000 Aarhus, Denmark

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2014年 / 65卷 / 01期

关键词：

HIV-2; HIV-1; Guinea-Bissau; HIV rapid tests; IMMUNODEFICIENCY-VIRUS TYPE-2; INFECTIONS;

D O I：

10.1097/QAI.0b013e3182a97b81

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As HIV-2 is intrinsically resistant to nonnucleoside reverse transcriptase inhibitors, it is mandatory to discriminate between HIV types before initiating antiretroviral treatment. Guinea-Bissau has the world's highest prevalence of HIV-2 and HIV-1/HIV-2 dually infected individuals. We evaluated 3 rapid tests for discrimination between HIV-1, HIV-2, and dual infections among 219 patients from Guinea-Bissau by comparing with the gold standard (INNO-LIA). Genie III HIV-1/HIV-2 was the best performer with regard to discriminatory capacity (agreement 91.8%), followed by Immunoflow HIV1-HIV2 (agreement 90.9%) and SD Bioline HIV-1/2 3.0 (agreement 84.5%). Our results underscore the need for evaluation of tests in relevant populations before implementation.

引用

页码：87 / 90

页数：4

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