Acute febrile illness caused by hantavirus: serological and molecular evidence from India

被引：12

作者：

Chandy, Sara ^{[1
]}

Yoshimatsu, Kumiko ^{[2
]}

Boorugu, Hari Kishan ^{[3
]}

Chrispal, Anugrah ^{[3
]}

Thomas, Kurien ^{[3
]}

Peedicayil, Abraham ^{[4
]}

Abraham, Priya ^{[1
]}

Arikawa, Jiro ^{[2
]}

Sridharan, Gopalan ^{[1
]}

机构：

[1] Christian Med Coll & Hosp, Dept Clin Virol, Vellore 632004, Tamil Nadu, India

[2] Hokkaido Univ, Grad Sch Med, Inst Anim Experimentat, Sapporo, Hokkaido, Japan

[3] Christian Med Coll & Hosp, Dept Med, Vellore 632004, Tamil Nadu, India

[4] Christian Med Coll & Hosp, Dept Obstet & Gynecol, Vellore 632004, Tamil Nadu, India

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2009年 / 103卷 / 04期

关键词：

Hantavirus; Haemorrhagic fever with renal syndrome; Diagnosis; Serological tests; RT-PCR; India; HEMORRHAGIC-FEVER; RENAL SYNDROME; VIRUS; INFECTIONS; HANTAAN; PROTEIN;

D O I：

10.1016/j.trstmh.2009.01.016

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Study of hantavirus infections in India is in its early stages. As early symptoms of hantavirus disease can be non-specific and the diagnosis confirmed only by laboratory testing, use of appropriate diagnostic toots is important. To improve the diagnosis of hantavirus infections in India, commercial ELISA systems followed by indirect immunofluorescence assays were used to detect anti-hantavirus IgM and IgG in samples from patients with acute febrile illness. Of 347 patients tested, 5.2% showed serological evidence of hantavirus infection. Sequences obtained from patients showing molecular evidence of hantavirus infection were related to Hantaan virus. In the absence of mu-capture ELISA, we recommend the use of combination testing systems in areas non-endemic for hantavirus infections. In India there is an increased risk of rodent-borne infections and the differential diagnosis of undifferentiated febrile illness should include hantavirus infection. (C) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：407 / 412

页数：6

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