Synthesis of Some New Heterocyclic Compounds Derived from 3-Formylchromones and Their Antimicrobial Evaluation

被引：16

作者：

Bari, A. ^{[1
,2
]}

Ali, S. S. ^{[2
]}

Kadi, A. ^{[1
]}

Hashmi, I. A. ^{[3
]}

Ng, S. W. ^{[4
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

[2] King Saud Univ, Coll Pharm, Res Ctr, Riyadh 11451, Saudi Arabia

[3] Univ Karachi, Dept Chem, Karachi 75270, Pakistan

[4] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2014年 / 49卷 / 12期

关键词：

3-formylchromone; pyranopyrones; antimicrobial activity; enzyme inhibitors; Knoevenagel-Cope reaction; pharmacophore; urease inhibitory; ACTIVE METHYLENE; INDUCTION; SERIES;

D O I：

10.1007/s10593-014-1424-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and antimicrobial evaluation of a series of chromone-linked substituted heterocyclic derivatives is described. The condensation of 3-formylchromone with acetoacetamide under Knoevenagel-Cope reaction conditions was also explored, and the condensation with 4-hydroxy-6-methyl-2H-pyran-2-one constitutes a facile route to pyranopyrone fused systems. Most of the compounds exhibit good antimicrobial properties.

引用

页码：1723 / 1731

页数：9

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