Using genetic variation for establishing causality of cardiovascular risk factors: overcoming confounding and reverse causality

被引：12

作者：

Smit, R. A. J. ^{[1
,2
]}

Trompet, S. ^{[1
,2
,3
]}

de Craen, A. J. M. ^{[1
]}

Jukema, J. W. ^{[2
,3
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, NL-2333 ZA Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Cardiol, NL-2333 ZA Leiden, Netherlands

[3] Interuniv Cardiol Inst Netherlands, Utrecht, Netherlands

来源：

NETHERLANDS HEART JOURNAL | 2014年 / 22卷 / 04期

关键词：

Cardiovascular risk assessment; Genetics; Instrumental variable analysis; Mendelian randomisation; CORONARY-HEART-DISEASE; MENDELIAN RANDOMIZATION; INSTRUMENTAL VARIABLES; BLOOD-PRESSURE; TRIAL; CHOLESTEROL; VARIANTS; CANCER; LOCI;

D O I：

10.1007/s12471-014-0534-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular disease (CVD) remains the leading cause of death in developed countries, despite the decline of CVD mortality over the last two decades. From observational, predictive research, efforts have been made to find causal risk factors for CVD. However, in recent years, some of these findings have been shown to be mistaken. Possible explanations for the discrepant findings are confounding and reverse causation. Genetic epidemiology has tried to address these problems through the use of Mendelian randomisation. In this paper, we discuss the promise and limitations of using genetic variation for establishing causality of cardiovascular risk factors.

引用

页码：186 / 189

页数：4

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