STAT inhibitors for cancer therapy

被引：152

作者：

Furqan, Muhammad ^{[1
,2
]}

Akinleye, Akintunde ^{[1
,2
]}

Mukhi, Nikhil ^{[3
]}

Mittal, Varun ^{[1
,2
]}

Chen, Yamei ^{[1
,2
,4
]}

Liu, Delong ^{[1
,2
,5
]}

机构：

[1] New York Med Coll, Dept Med, Valhalla, NY 10595 USA

[2] Westchester Med Ctr, Valhalla, NY 10595 USA

[3] Suny Downstate Med Ctr, Dept Med, Brooklyn, NY 11203 USA

[4] Xiamen Univ, Dept Hematol, Xiamen Zhongshan Hosp, Xiamen, Peoples R China

[5] New York Med Coll, Dept Med, Div Hematol & Oncol, Valhalla, NY 10595 USA

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2013年 / 6卷

关键词：

GROWTH-SUPPRESSIVE ACTIVITY; CONSTITUTIVE SIGNAL TRANSDUCER; HUMAN RHABDOMYOSARCOMA CELLS; SMALL-MOLECULE INHIBITORS; DNA-BINDING ACTIVITY; PROSTATE-CANCER; BREAST-CANCER; DECOY OLIGONUCLEOTIDE; PEPTIDOMIMETIC INHIBITORS; ANTITUMOR-ACTIVITY;

D O I：

10.1186/1756-8722-6-90

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Signal Transducer and Activator of Transcription (STAT) proteins are a family of cytoplasmic transcription factors consisting of 7 members, STAT1 to STAT6, including STAT5a and STAT5b. STAT proteins are thought to be ideal targets for anti-cancer therapy since cancer cells are more dependent on the STAT activity than their normal counterparts. Inhibitors targeting STAT3 and STAT5 have been developed. These included peptidomimetics, small molecule inhibitors and oligonucleotides. This review summarized advances in preclinical and clinical development of these compounds.

引用

页数：11

共 93 条

[21] G-quartet oligonucleotides: A new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis [J].

Jing, NJ ;

Li, YD ;

Xiong, WJ ;

Sha, W ;

Jing, L ;

Tweardy, DJ .

CANCER RESEARCH, 2004, 64 (18) :6603-6609

[22] Repression of STAT3, STAT5A, and STAT5B expressions in chronic myelogenous leukemia cell line K-562 with unmodified or chemically modified siRNAs and induction of apoptosis [J].

Kaymaz, Burcin Tezcanli ;

Selvi, Nur ;

Gunduz, Cumhur ;

Aktan, Cagdas ;

Dalmizrak, Aysegul ;

Saydam, Guray ;

Kosova, Buket .

ANNALS OF HEMATOLOGY, 2013, 92 (02) :151-162

[23] Stat3 as a molecular target in RNA interference-based treatment of oral squamous cell carcinoma [J].

Klosek, Sebastian Krystian ;

Nakashiro, Koh-Ichi ;

Hara, Shingo ;

Goda, Hiroyuki ;

Hamakawa, Hiroyuki .

ONCOLOGY REPORTS, 2008, 20 (04) :873-878

[24] Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells [J].

Konnikova, L ;

Kotecki, M ;

Kruger, MM ;

Cochran, BH .

BMC CANCER, 2003, 3 (1)

[25] Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer [J].

Kunigal, Sateesh ;

Lakka, Sajani S. ;

Sodadasu, Prasanna Kumar ;

Estes, Norman ;

Rao, Jasti S. .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2009, 34 (05) :1209-1220

[26]

Lamba G, 2012, EXP HEMATOL ONCOL, V1, DOI 10.1186/2162-3619-1-14

[27] Recent advances and novel agents for gastrointestinal stromal tumor (GIST) [J].

Lamba, Gurpreet ;

Ambrale, Samir ;

Lee, Byung ;

Gupta, Ridhi ;

Rafiyath, Shamudheen M. ;

Liu, Delong .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2012, 5

[28] STAT-3 Inhibitors: State of the Art and New Horizons for Cancer Treatment [J].

Lavecchia, A. ;

Di Giovanni, C. ;

Novellino, E. .

CURRENT MEDICINAL CHEMISTRY, 2011, 18 (16) :2359-2375

[29] Current management and novel agents for malignant melanoma [J].

Lee, Byung ;

Mukhi, Nikhil ;

Liu, Delong .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2012, 5

[30] Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth [J].

Leong, PL ;

Andrews, GA ;

Johnson, DE ;

Dyer, KF ;

Xi, SC ;

Mai, JC ;

Robbins, PD ;

Gadiparthi, S ;

Burke, NA ;

Watkins, SF ;

Grandis, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :4138-4143

← 1 2 3 4 5 6 7 8 9 10 →