Assessment of the feasibility of a rehabilitation intervention program for breast cancer survivors with cognitive complaints

被引:42
作者
Ercoli, Linda M. [1 ,2 ]
Castellon, Steven A. [3 ,4 ]
Hunter, Aimee M. [1 ,2 ,5 ,6 ]
Kwan, Lorna [7 ]
Kahn-Mills, Barbara A. [7 ]
Cernin, Paul A. [1 ,2 ]
Leuchter, Andrew F. [1 ,2 ,5 ,6 ]
Ganz, Patricia A. [7 ,8 ,9 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychol, Los Angeles, CA 90095 USA
[4] VA Greater Los Angeles Hlth Care Syst, Dept Psychiat & Mental Hlth, Los Angeles, CA USA
[5] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Lab Brain Behav & Pharmacol, Los Angeles, CA 90024 USA
[6] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Depress Res & Clin Program, Los Angeles, CA 90024 USA
[7] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA
[8] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA
[9] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA
关键词
Breast cancer; Chemotherapy; Cognitive; qEEG; Rehabilitation; Intervention; ADJUVANT CHEMOTHERAPY; MEMORY; DYSFUNCTION; PERFORMANCE; MANAGEMENT; WOMEN;
D O I
10.1007/s11682-013-9237-0
中图分类号
R445 [影像诊断学];
学科分类号
100207 ;
摘要
To assess the feasibility of a cognitive rehabilitation program in breast cancer survivors (BCS) with persistent post-treatment cognitive complaints. BCS with cognitive complaints, 18-months to 5-years post-treatment, were recruited for a once-weekly, five-week, group cognitive training intervention. Outcome measures included self-reported mood and cognitive function, and neurocognitive tests administered at pre-intervention, immediate-, two-month and four-month post-intervention. A sub-study in eight participants evaluated resting state quantitative electroencephalography (qEEG) changes from pre- to immediate post-intervention in relationship to post-intervention changes in cognitive complaints. Twenty-seven BCS completed the protocol and tolerated the intervention well. We observed significant reductions in total and memory-specific cognitive complaints from pre-intervention to immediate post-intervention (p = 0.031 and p = 0.009, respectively) and at four-months post-intervention (p < 0.0001 and p < 0.001, respectively). Significant improvement in neurocognitive tests were found for Symbol Digit, Stroop, and Trails A tests (df = 26, all p's < 0.05). Effect sizes for changes from pre-intervention to immediate and to four-month post intervention ranged from 0.429 to 0.607, and from 0.439 to 0.741, respectively. Increase in qEEG absolute alpha power over the course of the intervention was associated with reduced complaints at immediate post-intervention (r = -0.78, p = 0.021), two-months (r range = -0.76 to -0.82, p-value range 0.004 to 0.03), and four-months (r = -0.71, p = 0.048). A five-week group cognitive training intervention is feasible and well tolerated. Cognitive complaints and neurocognitive test performances showed positive changes. qEEG may serve as a potential biomarker for improvement in self-reported complaints. A randomized clinical trial is underway to test the efficacy of the intervention.
引用
收藏
页码:543 / 553
页数:11
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