Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck

被引：54

作者：

Calderwood, DJ ^{[1
]}

Johnston, DN ^{[1
]}

Munschauer, R ^{[1
]}

Rafferty, P ^{[1
]}

机构：

[1] Abbott Biores Ctr, Worcester, MA 01605 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00195-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available lck inhibitor which inhibited TCR mediated IL-2 production after oral dosing. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：1683 / 1686

页数：4

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